Gene description for GSTP1
Gene name glutathione S-transferase pi 1
Gene symbol GSTP1
Other names/aliases -
Species Bos taurus
 Database cross references - GSTP1
ExoCarta ExoCarta_281806
Entrez Gene 281806
UniProt P28801  
 GSTP1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for GSTP1
Molecular Function
    dinitrosyl-iron complex binding GO:0035731 IEA
    glutathione transferase activity GO:0004364 IEA
    S-nitrosoglutathione binding GO:0035730 IEA
Biological Process
    negative regulation of monocyte chemotactic protein-1 production GO:0071638 IEA
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA
    negative regulation of JUN kinase activity GO:0043508 IEA
    glutathione metabolic process GO:0006749 IEA
    negative regulation of tumor necrosis factor production GO:0032720 IEA
    negative regulation of interleukin-1 beta production GO:0032691 IEA
    xenobiotic metabolic process GO:0006805 IEA
    negative regulation of nitric-oxide synthase biosynthetic process GO:0051771 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IEA
    TRAF2-GSTP1 complex GO:0097057 IEA
    nucleus GO:0005634 IEA
    mitochondrion GO:0005739 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified GSTP1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GSTP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GSTP1 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
Glutathione conjugation IEA Reactome





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