Gene description for IMPA1
Gene name inositol(myo)-1(or 4)-monophosphatase 1
Gene symbol IMPA1
Other names/aliases -
Species Bos taurus
 Database cross references - IMPA1
ExoCarta ExoCarta_281865
Entrez Gene 281865
UniProt P20456  
 IMPA1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for IMPA1
Molecular Function
    magnesium ion binding GO:0000287 IDA
    inositol monophosphate phosphatase activity GO:0052834 IDA
    lithium ion binding GO:0031403 IDA
    inositol monophosphate 3-phosphatase activity GO:0052832 IEA
    inositol monophosphate 4-phosphatase activity GO:0052833 IEA
    manganese ion binding GO:0030145 IDA
    protein homodimerization activity GO:0042803 IEA
    inositol monophosphate 1-phosphatase activity GO:0008934 IEA
Biological Process
    inositol biosynthetic process GO:0006021 IEA
    phosphatidylinositol phosphorylation GO:0046854 IEA
    inositol phosphate dephosphorylation GO:0046855 IDA
    phosphatidylinositol biosynthetic process GO:0006661 IEA
    signal transduction GO:0007165 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified IMPA1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IMPA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IMPA1 is involved
PathwayEvidenceSource
Synthesis of IP2, IP, and Ins in the cytosol IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here