Gene description for ITGB1
Gene name integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Gene symbol ITGB1
Other names/aliases -
Species Bos taurus
 Database cross references - ITGB1
ExoCarta ExoCarta_281876
Entrez Gene 281876
UniProt P53712  
 ITGB1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ITGB1
Molecular Function
    protein heterodimerization activity GO:0046982 ISS
    protease binding GO:0002020 IEA
    collagen binding involved in cell-matrix adhesion GO:0098639 IEA
    integrin binding GO:0005178 IEA
    metal ion binding GO:0046872 IEA
    virus receptor activity GO:0001618 IEA
    actin binding GO:0003779 IEA
    laminin binding GO:0043236 IEA
Biological Process
    negative regulation of Rho protein signal transduction GO:0035024 IEA
    cell migration involved in sprouting angiogenesis GO:0002042 IEA
    G1/S transition of mitotic cell cycle GO:0000082 IEA
    leukocyte tethering or rolling GO:0050901 IEA
    mesodermal cell differentiation GO:0048333 IEA
    formation of radial glial scaffolds GO:0021943 IEA
    positive regulation of cell proliferation GO:0008284 IEA
    cell-cell adhesion mediated by integrin GO:0033631 IEA
    visual learning GO:0008542 IEA
    germ cell migration GO:0008354 IEA
    cardiac muscle cell differentiation GO:0055007 IEA
    cell fate specification GO:0001708 IEA
    viral entry into host cell GO:0046718 IEA
    positive regulation of establishment of protein localization to plasma membrane GO:0090004 ISS
    calcium-independent cell-matrix adhesion GO:0007161 IEA
    regulation of collagen catabolic process GO:0010710 ISS
    negative regulation of anoikis GO:2000811 IEA
    heterotypic cell-cell adhesion GO:0034113 IEA
    regulation of cell cycle GO:0051726 IEA
    in utero embryonic development GO:0001701 IEA
    integrin-mediated signaling pathway GO:0007229 IEA
    sarcomere organization GO:0045214 IEA
    axon extension GO:0048675 IEA
    dendrite morphogenesis GO:0048813 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    negative regulation of cell differentiation GO:0045596 IEA
Subcellular Localization
    myelin sheath abaxonal region GO:0035748 IEA
    intercalated disc GO:0014704 IEA
    recycling endosome GO:0055037 IEA
    integrin alpha10-beta1 complex GO:0034680 IEA
    neuromuscular junction GO:0031594 IEA
    focal adhesion GO:0005925 IEA
    synaptic membrane GO:0097060 IEA
    ruffle membrane GO:0032587 IEA
    lamellipodium GO:0030027 IEA
    membrane raft GO:0045121 IEA
    integrin alpha11-beta1 complex GO:0034681 IEA
    integrin alpha1-beta1 complex GO:0034665 IEA
    invadopodium membrane GO:0071438 ISS
    melanosome GO:0042470 IEA
    filopodium GO:0030175 IEA
    extracellular exosome GO:0070062 IEA
    sarcolemma GO:0042383 IEA
    integrin alpha3-beta1 complex GO:0034667 IEA
    external side of plasma membrane GO:0009897 IEA
    dendritic spine GO:0043197 IEA
    integrin alpha2-beta1 complex GO:0034666 IEA
    integrin alpha7-beta1 complex GO:0034677 IEA
 Experiment description of studies that identified ITGB1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITGB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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