Gene description for ITGB2
Gene name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene symbol ITGB2
Other names/aliases -
Species Bos taurus
 Database cross references - ITGB2
ExoCarta ExoCarta_281877
Entrez Gene 281877
UniProt P32592  
 ITGB2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ITGB2
Molecular Function
    protein kinase binding GO:0019901 IEA
    ICAM-3 receptor activity GO:0030369 IEA
    metal ion binding GO:0046872 IEA
    glycoprotein binding GO:0001948 IEA
    cell adhesion molecule binding GO:0050839 IEA
Biological Process
    endodermal cell differentiation GO:0035987 IEA
    neutrophil chemotaxis GO:0030593 IEA
    cellular extravasation GO:0045123 IEA
    activated T cell proliferation GO:0050798 IEA
    integrin-mediated signaling pathway GO:0007229 IEA
    receptor clustering GO:0043113 IEA
    cell-matrix adhesion GO:0007160 IEA
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 IEA
    heterotypic cell-cell adhesion GO:0034113 IEA
Subcellular Localization
    cell surface GO:0009986 IEA
    integrin alphaL-beta2 complex GO:0034687 IEA
    membrane raft GO:0045121 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified ITGB2 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITGB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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