Gene description for PPM1A
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene symbol PPM1A
Other names/aliases PP2C-alpha
Species Bos taurus
 Database cross references - PPM1A
ExoCarta ExoCarta_281994
Entrez Gene 281994
UniProt O62829  
 PPM1A identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPM1A
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IEA
    R-SMAD binding GO:0070412 ISS
    phosphoprotein phosphatase activity GO:0004721 ISS
    manganese ion binding GO:0030145 IEA
    signal transducer activity GO:0004871 ISS
    magnesium ion binding GO:0000287 IEA
Biological Process
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISS
    signal transduction GO:0007165 ISS
    negative regulation of NF-kappaB import into nucleus GO:0042347 ISS
    protein dephosphorylation GO:0006470 ISS
    N-terminal protein myristoylation GO:0006499 ISS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISS
Subcellular Localization
    cytosol GO:0005829 ISS
    membrane GO:0016020 ISS
    nucleus GO:0005634 IEA
 Experiment description of studies that identified PPM1A in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPM1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPM1A is involved
PathwayEvidenceSource
Downregulation of SMAD2/3:SMAD4 transcriptional activity IEA Reactome
Regulation of AMPK activity via LKB1 IEA Reactome





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