Gene description for PPM1B
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1B
Gene symbol PPM1B
Other names/aliases -
Species Bos taurus
 Database cross references - PPM1B
ExoCarta ExoCarta_281995
Entrez Gene 281995
UniProt O62830  
 PPM1B identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPM1B
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IEA
    magnesium ion binding GO:0000287 IEA
    manganese ion binding GO:0030145 IEA
Biological Process
    negative regulation of interferon-beta production GO:0032688 ISS
    protein dephosphorylation GO:0006470 ISS
    peptidyl-threonine dephosphorylation GO:0035970 IEA
    negative regulation of defense response to virus GO:0050687 ISS
    negative regulation of NF-kappaB import into nucleus GO:0042347 ISS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISS
    N-terminal protein myristoylation GO:0006499 ISS
Subcellular Localization
    membrane GO:0016020 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified PPM1B in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPM1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPM1B is involved
PathwayEvidenceSource
ISG15 antiviral mechanism IEA Reactome





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