Gene description for PPM1B
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1B
Gene symbol PPM1B
Other names/aliases -
Species Bos taurus
 Database cross references - PPM1B
ExoCarta ExoCarta_281995
Entrez Gene 281995
UniProt O62830  
 PPM1B identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPM1B
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IEA
    magnesium ion binding GO:0000287 IEA
    manganese ion binding GO:0030145 IEA
Biological Process
    negative regulation of interferon-beta production GO:0032688 ISS
    protein dephosphorylation GO:0006470 ISS
    peptidyl-threonine dephosphorylation GO:0035970 IEA
    negative regulation of defense response to virus GO:0050687 ISS
    negative regulation of NF-kappaB import into nucleus GO:0042347 ISS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISS
    N-terminal protein myristoylation GO:0006499 ISS
Subcellular Localization
    membrane GO:0016020 ISS
    cytosol GO:0005829 ISS
 Experiment description of studies that identified PPM1B in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPM1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PPM1B is involved
ISG15 antiviral mechanism IEA Reactome

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