Gene description for PSMC5
Gene name proteasome (prosome, macropain) 26S subunit, ATPase, 5
Gene symbol PSMC5
Other names/aliases -
Species Bos taurus
 Database cross references - PSMC5
ExoCarta ExoCarta_282015
Entrez Gene 282015
UniProt P62194  
 PSMC5 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PSMC5
Molecular Function
    thyrotropin-releasing hormone receptor binding GO:0031531 ISS
    proteasome-activating ATPase activity GO:0036402 IBA
    ATP binding GO:0005524 IEA
    transcription factor binding GO:0008134 ISS
    TBP-class protein binding GO:0017025 IBA
Biological Process
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 IBA
    negative regulation of transcription, DNA-templated GO:0045892 IEA
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 IBA
    positive regulation of proteasomal protein catabolic process GO:1901800 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
Subcellular Localization
    proteasome accessory complex GO:0022624 ISS
    nuclear proteasome complex GO:0031595 IBA
    nucleus GO:0005634 ISS
    proteasome complex GO:0000502 ISS
    membrane GO:0016020 IEA
    cytoplasmic vesicle GO:0031410 IEA
    cytosolic proteasome complex GO:0031597 IBA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IEA
    proteasome regulatory particle, base subcomplex GO:0008540 IBA
    blood microparticle GO:0072562 IEA
 Experiment description of studies that identified PSMC5 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PSMC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PSMC5 is involved
Activation of NF-kappaB in B cells IEA Reactome
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome
APC/C:Cdc20 mediated degradation of Securin IEA Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 IEA Reactome
Asymmetric localization of PCP proteins IEA Reactome
AUF1 (hnRNP D0) destabilizes mRNA IEA Reactome
Autodegradation of Cdh1 by Cdh1:APC/C IEA Reactome
Autodegradation of the E3 ubiquitin ligase COP1 IEA Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A IEA Reactome
CDK-mediated phosphorylation and removal of Cdc6 IEA Reactome
CDK-mediated phosphorylation and removal of Cdc6 IEA Reactome
CDT1 association with the CDC6:ORC:origin complex IEA Reactome
CLEC7A (Dectin-1) signaling IEA Reactome
Cross-presentation of soluble exogenous antigens (endosomes) IEA Reactome
Dectin-1 mediated noncanonical NF-kB signaling IEA Reactome
degradation of AXIN IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
degradation of DVL IEA Reactome
Degradation of GLI1 by the proteasome IEA Reactome
Degradation of GLI2 by the proteasome IEA Reactome
ER-Phagosome pathway IEA Reactome
GLI3 is processed to GLI3R by the proteasome IEA Reactome
Hedgehog 'on' state IEA Reactome
Hedgehog ligand biogenesis IEA Reactome
Orc1 removal from chromatin IEA Reactome
Orc1 removal from chromatin IEA Reactome
Regulation of activated PAK-2p34 by proteasome mediated degradation IEA Reactome
Regulation of ornithine decarboxylase (ODC) IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 IEA Reactome
SCF(Skp2)-mediated degradation of p27/p21 IEA Reactome
Separation of Sister Chromatids IEA Reactome
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A IEA Reactome
Ubiquitin-dependent degradation of Cyclin D1 IEA Reactome

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