Gene description for RAP1A
Gene name RAP1A, member of RAS oncogene family
Gene symbol RAP1A
Other names/aliases -
Species Bos taurus
 Database cross references - RAP1A
ExoCarta ExoCarta_282031
Entrez Gene 282031
UniProt P62833  
 RAP1A identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for RAP1A
Molecular Function
    protein complex binding GO:0032403 ISS
    GTPase activity GO:0003924 IEA
    Ras GTPase binding GO:0017016 IEA
    Rap guanyl-nucleotide exchange factor activity GO:0017034 ISS
    protein transporter activity GO:0008565 ISS
    GTP binding GO:0005525 IEA
Biological Process
    positive regulation of vasculogenesis GO:2001214 ISS
    positive regulation of protein kinase activity GO:0045860 ISS
    Rap protein signal transduction GO:0032486 ISS
    positive regulation of neuron projection development GO:0010976 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    cellular response to nerve growth factor stimulus GO:1990090 ISS
    nerve growth factor signaling pathway GO:0038180 ISS
    cellular response to cAMP GO:0071320 ISS
    regulation of cell junction assembly GO:1901888 ISS
    establishment of endothelial barrier GO:0061028 ISS
    metabolic process GO:0008152 IEA
    negative regulation of synaptic vesicle exocytosis GO:2000301 IEA
    positive regulation of GTPase activity GO:0043547 ISS
    protein transport GO:0015031 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    guanyl-nucleotide exchange factor complex GO:0032045 IEA
    perinuclear region of cytoplasm GO:0048471 ISS
    cell junction GO:0030054 ISS
    late endosome GO:0005770 ISS
    plasma membrane GO:0005886 IEA
    early endosome GO:0005769 ISS
    cytoplasm GO:0005737 ISS
    neuron projection GO:0043005 IEA
 Experiment description of studies that identified RAP1A in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAP1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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