Gene description for ROCK2
Gene name Rho-associated, coiled-coil containing protein kinase 2
Gene symbol ROCK2
Other names/aliases ROCK-II
Species Bos taurus
 Database cross references - ROCK2
ExoCarta ExoCarta_282041
Vesiclepedia VP_282041
Entrez Gene 282041
UniProt Q28021  
 ROCK2 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ROCK2
Molecular Function
    ATP binding GO:0005524 IEA
    small GTPase binding GO:0031267 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
Biological Process
    mitotic cytokinesis GO:0000281 IEA
    smooth muscle contraction GO:0006939 IEA
    Rho protein signal transduction GO:0007266 IEA
    positive regulation of centrosome duplication GO:0010825 IEA
    peptidyl-threonine phosphorylation GO:0018107 IEA
    cortical actin cytoskeleton organization GO:0030866 IEA
    actomyosin structure organization GO:0031032 IEA
    regulation of actin cytoskeleton organization GO:0032956 IEA
    embryonic morphogenesis GO:0048598 IEA
    regulation of cell junction assembly GO:1901888 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified ROCK2 in sEVs
1
Experiment ID 213
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ROCK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ROCK2 is involved
No pathways found





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