Gene description for ROCK2
Gene name Rho-associated, coiled-coil containing protein kinase 2
Gene symbol ROCK2
Other names/aliases ROCK-II
Species Bos taurus
 Database cross references - ROCK2
ExoCarta ExoCarta_282041
Entrez Gene 282041
UniProt Q28021  
 ROCK2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ROCK2
Molecular Function
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    metal ion binding GO:0046872 IEA
    protein kinase activity GO:0004672 IDA
    Rho GTPase binding GO:0017048 IEA
Biological Process
    positive regulation of centrosome duplication GO:0010825 IEA
    regulation of circadian rhythm GO:0042752 ISS
    Rho protein signal transduction GO:0007266 IEA
    smooth muscle contraction GO:0006939 IEA
    protein phosphorylation GO:0006468 IEA
    rhythmic process GO:0048511 IEA
    regulation of actin cytoskeleton organization GO:0032956 IEA
    actin cytoskeleton organization GO:0030036 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    microtubule organizing center GO:0005815 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ROCK2 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ROCK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ROCK2 is involved
PathwayEvidenceSource
RHO GTPases Activate ROCKs IEA Reactome





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