Gene description for ROCK2
Gene name Rho-associated, coiled-coil containing protein kinase 2
Gene symbol ROCK2
Other names/aliases ROCK-II
Species Bos taurus
 Database cross references - ROCK2
ExoCarta ExoCarta_282041
Entrez Gene 282041
UniProt Q28021  
 ROCK2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ROCK2
Molecular Function
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IEA
    metal ion binding GO:0046872 IEA
    protein kinase activity GO:0004672 IDA
    Rho GTPase binding GO:0017048 IEA
Biological Process
    positive regulation of centrosome duplication GO:0010825 IEA
    regulation of circadian rhythm GO:0042752 ISS
    Rho protein signal transduction GO:0007266 IEA
    smooth muscle contraction GO:0006939 IEA
    protein phosphorylation GO:0006468 IEA
    rhythmic process GO:0048511 IEA
    regulation of actin cytoskeleton organization GO:0032956 IEA
    actin cytoskeleton organization GO:0030036 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    microtubule organizing center GO:0005815 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified ROCK2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ROCK2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ROCK2 is involved
PathwayEvidenceSource
RHO GTPases Activate ROCKs IEA Reactome





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