Gene description for TRPC4
Gene name transient receptor potential cation channel, subfamily C, member 4
Gene symbol TRPC4
Other names/aliases -
Species Bos taurus
 Database cross references - TRPC4
ExoCarta ExoCarta_282102
Entrez Gene 282102
UniProt P79100  
 TRPC4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TRPC4
Molecular Function
    cadherin binding GO:0045296 IEA
    inositol 1,4,5 trisphosphate binding GO:0070679 IBA
    store-operated calcium channel activity GO:0015279 IBA
    beta-catenin binding GO:0008013 IEA
Biological Process
    oligodendrocyte differentiation GO:0048709 IEA
    calcium ion transmembrane transport GO:0070588 IBA
    calcium ion import GO:0070509 IEA
    cytosolic calcium ion homeostasis GO:0051480 IBA
    gamma-aminobutyric acid secretion GO:0014051 IEA
    manganese ion transport GO:0006828 IBA
Subcellular Localization
    cell surface GO:0009986 IEA
    basolateral plasma membrane GO:0016323 IEA
    cell-cell junction GO:0005911 IEA
    cytosol GO:0005829 IBA
    cortical cytoskeleton GO:0030863 IEA
    integral component of plasma membrane GO:0005887 IBA
    calcium channel complex GO:0034704 IEA
    caveola GO:0005901 IEA
 Experiment description of studies that identified TRPC4 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRPC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRPC4 is involved
PathwayEvidenceSource
Role of second messengers in netrin-1 signaling IEA Reactome
TRP channels IEA Reactome





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