Gene description for TRPC4
Gene name transient receptor potential cation channel, subfamily C, member 4
Gene symbol TRPC4
Other names/aliases -
Species Bos taurus
 Database cross references - TRPC4
ExoCarta ExoCarta_282102
Entrez Gene 282102
UniProt P79100  
 TRPC4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for TRPC4
Molecular Function
    cadherin binding GO:0045296 IEA
    inositol 1,4,5 trisphosphate binding GO:0070679 IBA
    store-operated calcium channel activity GO:0015279 IBA
    beta-catenin binding GO:0008013 IEA
Biological Process
    oligodendrocyte differentiation GO:0048709 IEA
    calcium ion transmembrane transport GO:0070588 IBA
    calcium ion import GO:0070509 IEA
    cytosolic calcium ion homeostasis GO:0051480 IBA
    gamma-aminobutyric acid secretion GO:0014051 IEA
    manganese ion transport GO:0006828 IBA
Subcellular Localization
    cell surface GO:0009986 IEA
    basolateral plasma membrane GO:0016323 IEA
    cell-cell junction GO:0005911 IEA
    cytosol GO:0005829 IBA
    cortical cytoskeleton GO:0030863 IEA
    integral component of plasma membrane GO:0005887 IBA
    calcium channel complex GO:0034704 IEA
    caveola GO:0005901 IEA
 Experiment description of studies that identified TRPC4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRPC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRPC4 is involved
PathwayEvidenceSource
Role of second messengers in netrin-1 signaling IEA Reactome
TRP channels IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here