Gene description for VAMP2
Gene name vesicle-associated membrane protein 2 (synaptobrevin 2)
Gene symbol VAMP2
Other names/aliases -
Species Bos taurus
 Database cross references - VAMP2
ExoCarta ExoCarta_282116
Entrez Gene 282116
UniProt P63026  
 VAMP2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for VAMP2
Molecular Function
    calmodulin binding GO:0005516 IEA
    protein C-terminus binding GO:0008022 IPI
    phospholipid binding GO:0005543 IEA
    protein binding GO:0005515 IPI
    syntaxin binding GO:0019905 IPI
Biological Process
    regulation of exocytosis GO:0017157 IEA
    positive regulation of intracellular protein transport GO:0090316 IEA
    vasodilation GO:0042311 IMP
    regulation of delayed rectifier potassium channel activity GO:1902259 ISS
    calcium ion-dependent exocytosis GO:0017156 IEA
    cytochrome complex assembly GO:0017004 IMP
    membrane raft distribution GO:0031580 IMP
    Golgi to plasma membrane protein transport GO:0043001 IEA
    long-term synaptic potentiation GO:0060291 IEA
    synaptic vesicle exocytosis GO:0016079 IEA
    cellular response to insulin stimulus GO:0032869 IEA
    vesicle fusion GO:0006906 IMP
    signal transduction GO:0007165 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    neuron projection GO:0043005 IEA
    SNARE complex GO:0031201 ISS
    perinuclear region of cytoplasm GO:0048471 IEA
    synaptic vesicle membrane GO:0030672 IEA
    caveola GO:0005901 IDA
    trans-Golgi network GO:0005802 IEA
    voltage-gated potassium channel complex GO:0008076 ISS
    zymogen granule membrane GO:0042589 IEA
    synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044 IEA
    cell junction GO:0030054 IEA
 Experiment description of studies that identified VAMP2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VAMP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here