Gene description for YWHAE
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Gene symbol YWHAE
Other names/aliases -
Species Bos taurus
 Database cross references - YWHAE
ExoCarta ExoCarta_282125
Vesiclepedia VP_282125
Entrez Gene 282125
UniProt P62261  
 YWHAE identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for YWHAE
Biological Process
    signal transduction GO:0007165 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified YWHAE in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for YWHAE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPGR  
Affinity Capture-Western Bos taurus
View the network image/svg+xml
 Pathways in which YWHAE is involved
PathwayEvidenceSource
Activation of BAD and translocation to mitochondria IEA Reactome
Activation of BH3-only proteins IEA Reactome
Anchoring of the basal body to the plasma membrane IEA Reactome
Apoptosis IEA Reactome
AURKA Activation by TPX2 IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cell death signalling via NRAGE, NRIF and NADE IEA Reactome
Cellular response to heat stress IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Centrosome maturation IEA Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex IEA Reactome
Cilium Assembly IEA Reactome
Death Receptor Signaling IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M DNA damage checkpoint IEA Reactome
G2/M Transition IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HSF1 activation IEA Reactome
Intrinsic Pathway for Apoptosis IEA Reactome
Loss of Nlp from mitotic centrosomes IEA Reactome
Loss of proteins required for interphase microtubule organization from the centrosome IEA Reactome
M Phase IEA Reactome
Membrane Trafficking IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Prometaphase IEA Reactome
NADE modulates death signalling IEA Reactome
Organelle biogenesis and maintenance IEA Reactome
p75 NTR receptor-mediated signalling IEA Reactome
Programmed Cell Death IEA Reactome
RAB GEFs exchange GTP for GDP on RABs IEA Reactome
Rab regulation of trafficking IEA Reactome
Recruitment of mitotic centrosome proteins and complexes IEA Reactome
Recruitment of NuMA to mitotic centrosomes IEA Reactome
Regulation of HSF1-mediated heat shock response IEA Reactome
Regulation of PLK1 Activity at G2/M Transition IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction IEA Reactome
Signaling by Hippo IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
TP53 Regulates Metabolic Genes IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome
Vesicle-mediated transport IEA Reactome





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