Gene description for ADAM10
Gene name ADAM metallopeptidase domain 10
Gene symbol ADAM10
Other names/aliases ADAM 10
Species Bos taurus
 Database cross references - ADAM10
ExoCarta ExoCarta_282132
Entrez Gene 282132
UniProt Q10741  
 ADAM10 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ADAM10
Molecular Function
    SH3 domain binding GO:0017124 IEA
    metallopeptidase activity GO:0008237 ISS
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 ISS
    metalloendopeptidase activity GO:0004222 ISS
    endopeptidase activity GO:0004175 ISS
    protein homodimerization activity GO:0042803 ISS
    zinc ion binding GO:0008270 IEA
Biological Process
    positive regulation of cell proliferation GO:0008284 IEA
    membrane protein ectodomain proteolysis GO:0006509 ISS
    PMA-inducible membrane protein ectodomain proteolysis GO:0051088 IEA
    positive regulation of T cell chemotaxis GO:0010820 IEA
    constitutive protein ectodomain proteolysis GO:0051089 IEA
    Notch signaling pathway GO:0007219 ISS
    protein phosphorylation GO:0006468 ISS
    response to tumor necrosis factor GO:0034612 IEA
    in utero embryonic development GO:0001701 ISS
    positive regulation of cell growth GO:0030307 IEA
    negative regulation of cell adhesion GO:0007162 ISS
    monocyte activation GO:0042117 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    Golgi membrane GO:0000139 IEA
    integral component of membrane GO:0016021 IEA
    focal adhesion GO:0005925 IEA
    Golgi apparatus GO:0005794 ISS
    cell surface GO:0009986 ISS
    perinuclear endoplasmic reticulum GO:0097038 IEA
    cytoplasm GO:0005737 ISS
    postsynaptic density GO:0014069 IEA
    tetraspanin-enriched microdomain GO:0097197 IEA
    Golgi-associated vesicle GO:0005798 ISS
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified ADAM10 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADAM10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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