Gene description for ALOX15
Gene name arachidonate 15-lipoxygenase
Gene symbol ALOX15
Other names/aliases 15-LOX
ALOX12
Species Bos taurus
 Database cross references - ALOX15
ExoCarta ExoCarta_282139
Entrez Gene 282139
UniProt P27479  
 ALOX15 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ALOX15
Molecular Function
    iron ion binding GO:0005506 ISS
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
    arachidonate 15-lipoxygenase activity GO:0050473 ISS
    arachidonate 12-lipoxygenase activity GO:0004052 IDA
Biological Process
    positive regulation of actin filament polymerization GO:0030838 ISS
    ossification GO:0001503 ISS
    negative regulation of adaptive immune response GO:0002820 ISS
    lipoxin A4 biosynthetic process GO:2001303 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    arachidonic acid metabolic process GO:0019369 IDA
    cellular response to interleukin-13 GO:0035963 ISS
    positive regulation of cell-substrate adhesion GO:0010811 ISS
    oxidation-reduction process GO:0055114 IEA
    apoptotic cell clearance GO:0043277 ISS
    regulation of engulfment of apoptotic cell GO:1901074 ISS
    bone mineralization GO:0030282 ISS
    wound healing GO:0042060 ISS
    phosphatidylethanolamine biosynthetic process GO:0006646 ISS
    lipoxygenase pathway GO:0019372 IDA
    regulation of peroxisome proliferator activated receptor signaling pathway GO:0035358 ISS
    response to endoplasmic reticulum stress GO:0034976 ISS
    cellular response to calcium ion GO:0071277 ISS
Subcellular Localization
    membrane GO:0016020 ISS
    lipid particle GO:0005811 ISS
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISS
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified ALOX15 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ALOX15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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