Gene description for CATHL4
Gene name cathelicidin 4
Gene symbol CATHL4
Other names/aliases -
Species Bos taurus
 Database cross references - CATHL4
ExoCarta ExoCarta_282166
Vesiclepedia VP_282166
Entrez Gene 282166
UniProt P33046  
 CATHL4 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CATHL4
Molecular Function
    lipopolysaccharide binding GO:0001530 IEA
Biological Process
    innate immune response GO:0045087 IEA
    defense response to Gram-negative bacterium GO:0050829 IEA
    defense response to Gram-positive bacterium GO:0050830 IEA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CATHL4 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CATHL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CATHL4 is involved
PathwayEvidenceSource
Antimicrobial peptides IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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