Gene description for COL1A1
Gene name collagen, type I, alpha 1
Gene symbol COL1A1
Other names/aliases -
Species Bos taurus
 Database cross references - COL1A1
ExoCarta ExoCarta_282187
Entrez Gene 282187
UniProt P02453  
 COL1A1 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for COL1A1
Molecular Function
    identical protein binding GO:0042802 IEA
    extracellular matrix structural constituent GO:0005201 IEA
    platelet-derived growth factor binding GO:0048407 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    osteoblast differentiation GO:0001649 IEA
    cartilage development involved in endochondral bone morphogenesis GO:0060351 IEA
    positive regulation of cell migration GO:0030335 IEA
    endochondral ossification GO:0001958 IEA
    protein heterotrimerization GO:0070208 IEA
    protein transport GO:0015031 IEA
    visual perception GO:0007601 IEA
    blood vessel development GO:0001568 IEA
    sensory perception of sound GO:0007605 IEA
    intramembranous ossification GO:0001957 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    protein localization to nucleus GO:0034504 IEA
    collagen biosynthetic process GO:0032964 IEA
    embryonic skeletal system development GO:0048706 IEA
    positive regulation of epithelial to mesenchymal transition GO:0010718 IEA
    cellular response to amino acid stimulus GO:0071230 IEA
    collagen fibril organization GO:0030199 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    skin morphogenesis GO:0043589 IEA
    negative regulation of cell-substrate adhesion GO:0010812 IEA
    cellular response to mechanical stimulus GO:0071260 IEA
    tooth mineralization GO:0034505 IEA
    bone trabecula formation GO:0060346 IEA
    face morphogenesis GO:0060325 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    extracellular space GO:0005615 IEA
    collagen type I trimer GO:0005584 IEA
 Experiment description of studies that identified COL1A1 in exosomes
1
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COL1A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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