Gene description for PABPC1
Gene name poly(A) binding protein, cytoplasmic 1
Gene symbol PABPC1
Other names/aliases -
Species Bos taurus
 Database cross references - PABPC1
ExoCarta ExoCarta_282296
Entrez Gene 282296
UniProt P61286  
 PABPC1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PABPC1
Molecular Function
    poly(U) RNA binding GO:0008266 IEA
    poly(A) binding GO:0008143 IEA
    protein C-terminus binding GO:0008022 IEA
    poly(A) RNA binding GO:0044822 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
Biological Process
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 ISS
    negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:2000623 ISS
    RNA splicing GO:0008380 IEA
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 ISS
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IEA
    gene silencing by RNA GO:0031047 ISS
    mRNA processing GO:0006397 IEA
Subcellular Localization
    ribonucleoprotein complex GO:0030529 ISS
    membrane GO:0016020 IEA
    catalytic step 2 spliceosome GO:0071013 IEA
    extracellular exosome GO:0070062 IEA
    focal adhesion GO:0005925 IEA
    cytoplasmic stress granule GO:0010494 ISS
 Experiment description of studies that identified PABPC1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PABPC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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