Gene description for PGLYRP1
Gene name peptidoglycan recognition protein 1
Gene symbol PGLYRP1
Other names/aliases PGLYRP
Species Bos taurus
 Database cross references - PGLYRP1
ExoCarta ExoCarta_282305
Entrez Gene 282305
UniProt Q8SPP7  
 PGLYRP1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PGLYRP1
Molecular Function
    peptidoglycan receptor activity GO:0016019 IEA
    peptidoglycan binding GO:0042834 ISS
    N-acetylmuramoyl-L-alanine amidase activity GO:0008745 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    detection of bacterium GO:0016045 IEA
    negative regulation of interferon-gamma production GO:0032689 IEA
    pattern recognition receptor signaling pathway GO:0002221 IEA
    defense response to fungus GO:0050832 IEA
    growth of symbiont in host GO:0044117 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    killing of cells of other organism GO:0031640 IEA
    negative regulation of natural killer cell differentiation involved in immune response GO:0032827 IEA
    innate immune response GO:0045087 IEA
    peptidoglycan catabolic process GO:0009253 IEA
    defense response to Gram-positive bacterium GO:0050830 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PGLYRP1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PGLYRP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PGLYRP1 is involved
No pathways found

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