Gene description for PPP2CA
Gene name protein phosphatase 2, catalytic subunit, alpha isozyme
Gene symbol PPP2CA
Other names/aliases -
Species Bos taurus
 Database cross references - PPP2CA
ExoCarta ExoCarta_282320
Entrez Gene 282320
UniProt P67774  
 PPP2CA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPP2CA
Molecular Function
    GABA receptor binding GO:0050811 IEA
    phosphoprotein phosphatase activity GO:0004721 IEA
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 ISS
    protein C-terminus binding GO:0008022 IEA
Biological Process
    positive regulation of protein serine/threonine kinase activity GO:0071902 IEA
    mesoderm development GO:0007498 IEA
    negative regulation of epithelial to mesenchymal transition GO:0010719 IEA
    meiotic cell cycle GO:0051321 IEA
    dephosphorylation GO:0016311 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    spindle pole GO:0000922 IEA
    plasma membrane GO:0005886 IEA
    protein phosphatase type 2A complex GO:0000159 IEA
    cytosol GO:0005829 IEA
    chromosome, centromeric region GO:0000775 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PPP2CA in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2CA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here