Gene description for PPP2CA
Gene name protein phosphatase 2, catalytic subunit, alpha isozyme
Gene symbol PPP2CA
Other names/aliases -
Species Bos taurus
 Database cross references - PPP2CA
ExoCarta ExoCarta_282320
Vesiclepedia VP_282320
Entrez Gene 282320
UniProt P67774  
 PPP2CA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPP2CA
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IEA
Biological Process
    mitotic cell cycle GO:0000278 IEA
    peptidyl-serine dephosphorylation GO:0070262 IEA
Subcellular Localization
    cytosol GO:0005829 IEA
 Experiment description of studies that identified PPP2CA in exosomes
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2CA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GGA1 26088
Biochemical Activity Homo sapiens
2 MAPT  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2CA is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Antiviral mechanism by IFN-stimulated genes IEA Reactome
Beta-catenin phosphorylation cascade IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Costimulation by the CD28 family IEA Reactome
CTLA4 inhibitory signaling IEA Reactome
Cyclin A/B1/B2 associated events during G2/M transition IEA Reactome
Cyclin D associated events in G1 IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
DARPP-32 events IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
E2F mediated regulation of DNA replication IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
ERK/MAPK targets IEA Reactome
ERKs are inactivated IEA Reactome
G alpha (i) signalling events IEA Reactome
G1 Phase IEA Reactome
G1/S Transition IEA Reactome
G2/M Transition IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
GPCR downstream signalling IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Inhibition of replication initiation of damaged DNA by RB1/E2F1 IEA Reactome
Initiation of Nuclear Envelope (NE) Reformation IEA Reactome
Innate Immune System IEA Reactome
Interferon Signaling IEA Reactome
Interleukin-17 signaling IEA Reactome
Intracellular signaling by second messengers IEA Reactome
M Phase IEA Reactome
MAP kinase activation IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK targets/ Nuclear events mediated by MAP kinases IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
Metabolism of RNA IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Mitotic G2-G2/M phases IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
MyD88 cascade initiated on plasma membrane IEA Reactome
MyD88 dependent cascade initiated on endosome IEA Reactome
MyD88-independent TLR4 cascade IEA Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane IEA Reactome
Negative regulation of FGFR1 signaling IEA Reactome
Negative regulation of FGFR2 signaling IEA Reactome
Negative regulation of FGFR3 signaling IEA Reactome
Negative regulation of FGFR4 signaling IEA Reactome
Negative regulation of MAPK pathway IEA Reactome
Negative regulation of the PI3K/AKT network IEA Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) IEA Reactome
Nonsense-Mediated Decay (NMD) IEA Reactome
Nuclear Envelope (NE) Reassembly IEA Reactome
Nuclear Events (kinase and transcription factor activation) IEA Reactome
Opioid Signalling IEA Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IEA Reactome
PIP3 activates AKT signaling IEA Reactome
PKR-mediated signaling IEA Reactome
Platelet homeostasis IEA Reactome
Platelet sensitization by LDL IEA Reactome
RAF activation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Regulation of TP53 Activity IEA Reactome
Regulation of TP53 Degradation IEA Reactome
Regulation of TP53 Expression and Degradation IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by FGFR IEA Reactome
Signaling by FGFR1 IEA Reactome
Signaling by FGFR2 IEA Reactome
Signaling by FGFR3 IEA Reactome
Signaling by FGFR4 IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by WNT IEA Reactome
Spry regulation of FGF signaling IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade IEA Reactome
Toll Like Receptor 2 (TLR2) Cascade IEA Reactome
Toll Like Receptor 3 (TLR3) Cascade IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome
Toll Like Receptor 5 (TLR5) Cascade IEA Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade IEA Reactome
Toll Like Receptor 9 (TLR9) Cascade IEA Reactome
Toll Like Receptor TLR1:TLR2 Cascade IEA Reactome
Toll Like Receptor TLR6:TLR2 Cascade IEA Reactome
Toll-like Receptor Cascades IEA Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling IEA Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells IEA Reactome





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