Gene description for PPP2CA
Gene name protein phosphatase 2, catalytic subunit, alpha isozyme
Gene symbol PPP2CA
Other names/aliases -
Species Bos taurus
 Database cross references - PPP2CA
ExoCarta ExoCarta_282320
Entrez Gene 282320
UniProt P67774  
 PPP2CA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PPP2CA
Molecular Function
    GABA receptor binding GO:0050811 IEA
    phosphoprotein phosphatase activity GO:0004721 IEA
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 ISS
    protein C-terminus binding GO:0008022 IEA
Biological Process
    positive regulation of protein serine/threonine kinase activity GO:0071902 IEA
    mesoderm development GO:0007498 IEA
    negative regulation of epithelial to mesenchymal transition GO:0010719 IEA
    meiotic cell cycle GO:0051321 IEA
    dephosphorylation GO:0016311 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    spindle pole GO:0000922 IEA
    plasma membrane GO:0005886 IEA
    protein phosphatase type 2A complex GO:0000159 IEA
    cytosol GO:0005829 IEA
    chromosome, centromeric region GO:0000775 IEA
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified PPP2CA in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2CA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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