Gene description for PRKACA
Gene name protein kinase, cAMP-dependent, catalytic, alpha
Gene symbol PRKACA
Other names/aliases -
Species Bos taurus
 Database cross references - PRKACA
ExoCarta ExoCarta_282322
Entrez Gene 282322
UniProt P00517  
 PRKACA identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PRKACA
Molecular Function
    protein kinase A regulatory subunit binding GO:0034237 IEA
    protein kinase activity GO:0004672 ISS
    ubiquitin protein ligase binding GO:0031625 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 IEA
    cAMP-dependent protein kinase activity GO:0004691 ISS
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
    ATP binding GO:0005524 IEA
Biological Process
    protein phosphorylation GO:0006468 ISS
    negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:1901621 IEA
    neural tube closure GO:0001843 IEA
    protein autophosphorylation GO:0046777 IEA
    peptidyl-serine phosphorylation GO:0018105 IEA
    cellular response to glucose stimulus GO:0071333 IEA
    peptidyl-threonine phosphorylation GO:0018107 IEA
    sperm capacitation GO:0048240 IEA
    regulation of osteoblast differentiation GO:0045667 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    regulation of synaptic transmission GO:0050804 IEA
    mesoderm formation GO:0001707 ISS
    positive regulation of protein export from nucleus GO:0046827 IEA
    positive regulation of cell cycle arrest GO:0071158 IEA
    regulation of bicellular tight junction assembly GO:2000810 IEA
    regulation of proteasomal protein catabolic process GO:0061136 IEA
    regulation of protein processing GO:0070613 IEA
Subcellular Localization
    sperm midpiece GO:0097225 IEA
    centrosome GO:0005813 IEA
    ciliary base GO:0097546 IEA
    extracellular exosome GO:0070062 IEA
    plasma membrane GO:0005886 IEA
    mitochondrion GO:0005739 IEA
    neuromuscular junction GO:0031594 ISS
    AMP-activated protein kinase complex GO:0031588 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified PRKACA in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKACA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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