Gene description for SERPINF2
Gene name serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Gene symbol SERPINF2
Other names/aliases PLI
Species Bos taurus
 Database cross references - SERPINF2
ExoCarta ExoCarta_282522
Entrez Gene 282522
UniProt P28800  
 SERPINF2 identified in exosomes derived from the following tissue/cell type
Serum 19327352    
 Gene ontology annotations for SERPINF2
Molecular Function
    protein homodimerization activity GO:0042803 IEA
    protease binding GO:0002020 IEA
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
Biological Process
    acute-phase response GO:0006953 IEA
    negative regulation of endopeptidase activity GO:0010951 IBA
    positive regulation of smooth muscle cell proliferation GO:0048661 IEA
    positive regulation of JNK cascade GO:0046330 IEA
    positive regulation of cell differentiation GO:0045597 IEA
    positive regulation of collagen biosynthetic process GO:0032967 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    positive regulation of stress fiber assembly GO:0051496 IEA
    collagen fibril organization GO:0030199 IEA
    negative regulation of fibrinolysis GO:0051918 IEA
    negative regulation of plasminogen activation GO:0010757 IEA
    blood vessel morphogenesis GO:0048514 IEA
    regulation of blood vessel size by renin-angiotensin GO:0002034 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    positive regulation of transforming growth factor beta production GO:0071636 IEA
Subcellular Localization
    blood microparticle GO:0072562 IEA
    fibrinogen complex GO:0005577 IEA
    extracellular exosome GO:0070062 IEA
    extracellular space GO:0005615 IBA
    cell surface GO:0009986 IEA
 Experiment description of studies that identified SERPINF2 in exosomes
1
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SERPINF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERPINF2 is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot IEA Reactome
Platelet degranulation IEA Reactome





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