Gene description for HSP90B1
Gene name heat shock protein 90kDa beta (Grp94), member 1
Gene symbol HSP90B1
Other names/aliases TRA1
Species Bos taurus
 Database cross references - HSP90B1
ExoCarta ExoCarta_282646
Entrez Gene 282646
UniProt Q95M18  
 HSP90B1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for HSP90B1
Molecular Function
    RNA binding GO:0003723 ISS
    virion binding GO:0046790 IEA
    ATP binding GO:0005524 IEA
    unfolded protein binding GO:0051082 IEA
    low-density lipoprotein particle receptor binding GO:0050750 ISS
    protein phosphatase binding GO:0019903 IEA
Biological Process
    regulation of phosphoprotein phosphatase activity GO:0043666 IEA
    actin rod assembly GO:0031247 IEA
    negative regulation of apoptotic process GO:0043066 ISS
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 ISS
    response to hypoxia GO:0001666 ISS
    protein folding GO:0006457 IEA
    cellular response to ATP GO:0071318 IEA
Subcellular Localization
    extracellular matrix GO:0031012 IEA
    midbody GO:0030496 IEA
    melanosome GO:0042470 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum GO:0005783 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    extracellular exosome GO:0070062 IEA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IEA
    focal adhesion GO:0005925 IEA
    endoplasmic reticulum lumen GO:0005788 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified HSP90B1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSP90B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HSP90B1 is involved
PathwayEvidenceSource
Scavenging by Class A Receptors IEA Reactome
Trafficking and processing of endosomal TLR IEA Reactome





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