Gene description for PSEN1
Gene name presenilin 1
Gene symbol PSEN1
Other names/aliases -
Species Bos taurus
 Database cross references - PSEN1
ExoCarta ExoCarta_282705
Entrez Gene 282705
UniProt Q9XT97  
 PSEN1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PSEN1
Molecular Function
    PDZ domain binding GO:0030165 IEA
    beta-catenin binding GO:0008013 IBA
    aspartic-type endopeptidase activity GO:0004190 IEA
    calcium channel activity GO:0005262 IEA
    endopeptidase activity GO:0004175 IBA
    cadherin binding GO:0045296 IBA
Biological Process
    Notch receptor processing GO:0007220 IBA
    regulation of protein binding GO:0043393 IEA
    mitochondrial transport GO:0006839 IEA
    positive regulation of catalytic activity GO:0043085 ISS
    Cajal-Retzius cell differentiation GO:0021870 IEA
    negative regulation of epidermal growth factor-activated receptor activity GO:0007175 IEA
    thymus development GO:0048538 IEA
    somitogenesis GO:0001756 IEA
    amyloid precursor protein catabolic process GO:0042987 IBA
    negative regulation of apoptotic process GO:0043066 IBA
    protein processing GO:0016485 ISS
    neuron development GO:0048666 IEA
    cellular response to DNA damage stimulus GO:0006974 IEA
    negative regulation of axonogenesis GO:0050771 IEA
    blood vessel development GO:0001568 IEA
    autophagosome assembly GO:0000045 IEA
    membrane protein ectodomain proteolysis GO:0006509 ISS
    dorsal/ventral neural tube patterning GO:0021904 IEA
    intracellular signal transduction GO:0035556 IEA
    L-glutamate transport GO:0015813 IEA
    response to oxidative stress GO:0006979 IEA
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA
    negative regulation of apoptotic signaling pathway GO:2001234 IEA
    memory GO:0007613 IEA
    regulation of resting membrane potential GO:0060075 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    neuron apoptotic process GO:0051402 IEA
    regulation of synaptic transmission, glutamatergic GO:0051966 IEA
    positive regulation of MAP kinase activity GO:0043406 IEA
    canonical Wnt signaling pathway GO:0060070 IBA
    beta-amyloid formation GO:0034205 IEA
    choline transport GO:0015871 IEA
    brain morphogenesis GO:0048854 IEA
    neuron migration GO:0001764 IEA
    negative regulation of ubiquitin-protein transferase activity GO:0051444 IEA
    T cell receptor signaling pathway GO:0050852 IEA
    negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000059 IEA
    myeloid dendritic cell differentiation GO:0043011 IEA
    activation of MAPKK activity GO:0000186 IEA
    synaptic vesicle targeting GO:0016080 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 IBA
    T cell activation involved in immune response GO:0002286 IEA
    Notch signaling pathway GO:0007219 IEA
    positive regulation of receptor recycling GO:0001921 IEA
    skeletal system morphogenesis GO:0048705 IEA
    protein glycosylation GO:0006486 IEA
    cerebral cortex cell migration GO:0021795 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    embryonic limb morphogenesis GO:0030326 IEA
    epithelial cell proliferation GO:0050673 IEA
    positive regulation of coagulation GO:0050820 IEA
    heart looping GO:0001947 IEA
    post-embryonic development GO:0009791 IEA
    skin morphogenesis GO:0043589 IEA
    protein transport GO:0015031 IEA
    calcium ion transport GO:0006816 IBA
    beta-amyloid metabolic process GO:0050435 IBA
    cell fate specification GO:0001708 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    regulation of synaptic plasticity GO:0048167 IEA
Subcellular Localization
    Golgi apparatus GO:0005794 ISS
    lysosomal membrane GO:0005765 IBA
    integral component of plasma membrane GO:0005887 ISS
    perinuclear region of cytoplasm GO:0048471 IBA
    nucleus GO:0005634 IBA
    plasma membrane GO:0005886 ISS
    growth cone GO:0030426 IBA
    neuromuscular junction GO:0031594 IBA
    cytoplasmic vesicle GO:0031410 IEA
    centrosome GO:0005813 IEA
    smooth endoplasmic reticulum GO:0005790 IEA
    Z disc GO:0030018 IBA
    kinetochore GO:0000776 IEA
    cell surface GO:0009986 IBA
    mitochondrion GO:0005739 ISS
    axon GO:0030424 IBA
    dendritic shaft GO:0043198 IBA
    aggresome GO:0016235 ISS
    membrane raft GO:0045121 IBA
    Golgi membrane GO:0000139 IEA
    cell cortex GO:0005938 IBA
    rough endoplasmic reticulum GO:0005791 IEA
    endoplasmic reticulum GO:0005783 ISS
    neuronal cell body GO:0043025 IBA
    apical plasma membrane GO:0016324 IBA
    nuclear outer membrane GO:0005640 IEA
    mitochondrial inner membrane GO:0005743 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    gamma-secretase complex GO:0070765 IEA
    ciliary rootlet GO:0035253 IBA
 Experiment description of studies that identified PSEN1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PSEN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PSEN1 is involved
PathwayEvidenceSource
Degradation of the extracellular matrix IEA Reactome





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