Gene description for Chmp3
Gene name charged multivesicular body protein 3
Gene symbol Chmp3
Other names/aliases Vps24
Species Rattus norvegicus
 Database cross references - Chmp3
ExoCarta ExoCarta_282834
Entrez Gene 282834
UniProt Q8CGS4  
 Chmp3 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Chmp3
Molecular Function
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IMP
    phosphatidylcholine binding GO:0031210 ISO
    ubiquitin-specific protease binding GO:1990381 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    negative regulation of viral release from host cell GO:1902187 ISO
    regulation of viral process GO:0050792 ISO
    protein polymerization GO:0051258 ISO
    protein heterooligomerization GO:0051291 ISO
    regulation of centrosome duplication GO:0010824 ISO
    cell separation after cytokinesis GO:0000920 ISO
    positive regulation of cytokinesis GO:0032467 IMP
    regulation of exosomal secretion GO:1903541 ISO
    endosome to lysosome transport GO:0008333 IMP
    cell division GO:0051301 IEA
    regulation of mitotic spindle assembly GO:1901673 ISO
    regulation of endosome size GO:0051036 IMP
    nucleus organization GO:0006997 ISO
    viral budding via host ESCRT complex GO:0039702 ISO
    mitotic metaphase plate congression GO:0007080 ISO
    protein transport GO:0015031 IEA
    positive regulation of viral release from host cell GO:1902188 ISO
Subcellular Localization
    cytosol GO:0005829 IEA
    late endosome GO:0005770 IDA
    ESCRT III complex GO:0000815 ISO
    cytoplasmic membrane-bounded vesicle GO:0016023 ISO
    extracellular exosome GO:0070062 ISO
    plasma membrane GO:0005886 ISO
    late endosome membrane GO:0031902 IEA
    early endosome GO:0005769 IDA
    midbody GO:0030496 IDA
 Experiment description of studies that identified Chmp3 in exosomes
1
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Chmp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Chmp3 is involved
PathwayEvidenceSource
Endosomal Sorting Complex Required For Transport (ESCRT) IEA Reactome





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