Gene description for Chmp3
Gene name charged multivesicular body protein 3
Gene symbol Chmp3
Other names/aliases Vps24
Species Rattus norvegicus
 Database cross references - Chmp3
ExoCarta ExoCarta_282834
Vesiclepedia VP_282834
Entrez Gene 282834
UniProt Q8CGS4  
 Chmp3 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Chmp3
Molecular Function
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IMP
    phosphatidylcholine binding GO:0031210 ISO
    identical protein binding GO:0042802 ISO
    molecular function inhibitor activity GO:0140678 ISO
    ubiquitin-specific protease binding GO:1990381 ISO
Biological Process
    plasma membrane repair GO:0001778 ISO
    autophagy GO:0006914 ISO
    nucleus organization GO:0006997 ISO
    nucleus organization GO:0006997 ISO
    vacuolar transport GO:0007034 IEA
    mitotic metaphase chromosome alignment GO:0007080 ISO
    mitotic metaphase chromosome alignment GO:0007080 ISO
    endosome to lysosome transport GO:0008333 IMP
    regulation of centrosome duplication GO:0010824 ISO
    protein transport GO:0015031 IBA
    protein transport GO:0015031 IEA
    nuclear membrane reassembly GO:0031468 ISO
    positive regulation of cytokinesis GO:0032467 IMP
    endosome transport via multivesicular body sorting pathway GO:0032509 IBA
    viral budding via host ESCRT complex GO:0039702 ISO
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 ISO
    suppression of viral release by host GO:0044790 IEA
    late endosome to vacuole transport GO:0045324 IBA
    viral budding from plasma membrane GO:0046761 ISO
    regulation of endosome size GO:0051036 IMP
    protein polymerization GO:0051258 ISO
    multivesicular body-lysosome fusion GO:0061763 ISO
    midbody abscission GO:0061952 ISO
    multivesicular body sorting pathway GO:0071985 ISO
    autophagosome maturation GO:0097352 ISO
    regulation of mitotic spindle assembly GO:1901673 ISO
    regulation of mitotic spindle assembly GO:1901673 ISO
    late endosome to lysosome transport GO:1902774 ISO
    regulation of exosomal secretion GO:1903541 ISO
    regulation of early endosome to late endosome transport GO:2000641 ISO
Subcellular Localization
    autophagosome membrane GO:0000421 ISO
    kinetochore GO:0000776 ISO
    ESCRT III complex GO:0000815 IBA
    ESCRT III complex GO:0000815 IC
    ESCRT III complex GO:0000815 ISO
    nuclear pore GO:0005643 ISO
    lysosomal membrane GO:0005765 ISO
    early endosome GO:0005769 IDA
    late endosome GO:0005770 IDA
    late endosome GO:0005770 ISO
    multivesicular body GO:0005771 IBA
    kinetochore microtubule GO:0005828 ISO
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 ISO
    endosome membrane GO:0010008 IEA
    midbody GO:0030496 IDA
    midbody GO:0030496 ISO
    cytoplasmic vesicle GO:0031410 ISO
    multivesicular body membrane GO:0032585 ISO
    amphisome membrane GO:1904930 ISO
 Experiment description of studies that identified Chmp3 in exosomes
1
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Chmp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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