Gene description for Rffl
Gene name	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Gene symbol	Rffl
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Rffl
ExoCarta	ExoCarta_282844
Vesiclepedia	VP_282844
Entrez Gene	282844
UniProt	Q8CIN9
Rffl identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Rffl

Molecular Function     protease binding GO:0002020 IEA     protease binding GO:0002020 ISO     p53 binding GO:0002039 IEA     p53 binding GO:0002039 ISO     transferase activity GO:0016740 IEA     protein kinase binding GO:0019901 IEA     protein kinase binding GO:0019901 ISO     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     metal ion binding GO:0046872 IEA     ubiquitin protein ligase activity GO:0061630 IBA     ubiquitin protein ligase activity GO:0061630 IEA     ubiquitin protein ligase activity GO:0061630 ISO     ubiquitin protein ligase activity GO:0061630 ISS Biological Process     ubiquitin-dependent protein catabolic process GO:0006511 ISO     ubiquitin-dependent protein catabolic process GO:0006511 ISS     intracellular protein transport GO:0006886 ISO     apoptotic process GO:0006915 IEA     biological_process GO:0008150 ND     regulation of fibroblast migration GO:0010762 ISO     regulation of fibroblast migration GO:0010762 ISS     negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 IEA     negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 ISO     negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 ISS     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS     protein K48-linked ubiquitination GO:0070936 IEA     protein K48-linked ubiquitination GO:0070936 ISO     protein K48-linked ubiquitination GO:0070936 ISS     negative regulation of signal transduction by p53 class mediator GO:1901797 IEA     negative regulation of signal transduction by p53 class mediator GO:1901797 ISO     negative regulation of signal transduction by p53 class mediator GO:1901797 ISS     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IBA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISS     negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO     negative regulation of cysteine-type endopeptidase activity GO:2000117 ISS Subcellular Localization     Golgi membrane GO:0000139 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     lysosome GO:0005764 ISO     cytosol GO:0005829 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     endosome membrane GO:0010008 IEA     endosome membrane GO:0010008 ISO     endosome membrane GO:0010008 ISS     cytoplasmic vesicle GO:0031410 ISO     recycling endosome membrane GO:0055038 IEA