Gene description for UBA1
Gene name ubiquitin-like modifier activating enzyme 1
Gene symbol UBA1
Other names/aliases UBE1
Species Bos taurus
 Database cross references - UBA1
ExoCarta ExoCarta_282869
Entrez Gene 282869
UniProt A3KMV5  
 UBA1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for UBA1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IBA
    poly(A) RNA binding GO:0044822 IEA
    ubiquitin activating enzyme activity GO:0004839 IBA
    ATP binding GO:0005524 IEA
Biological Process
    protein ubiquitination GO:0016567 IEA
    modification-dependent protein catabolic process GO:0019941 IBA
    cellular response to DNA damage stimulus GO:0006974 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 IEA
    endosome membrane GO:0010008 IEA
    desmosome GO:0030057 IEA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IEA
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 IBA
    nucleus GO:0005634 ISS
    rough endoplasmic reticulum membrane GO:0030867 IEA
    heterochromatin GO:0000792 IEA
 Experiment description of studies that identified UBA1 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UBA1 is involved
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome

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