Gene description for UBA1
Gene name ubiquitin-like modifier activating enzyme 1
Gene symbol UBA1
Other names/aliases UBE1
UBE1X
Species Bos taurus
 Database cross references - UBA1
ExoCarta ExoCarta_282869
Entrez Gene 282869
UniProt A3KMV5  
 UBA1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for UBA1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IBA
    poly(A) RNA binding GO:0044822 IEA
    ubiquitin activating enzyme activity GO:0004839 IBA
    ATP binding GO:0005524 IEA
Biological Process
    protein ubiquitination GO:0016567 IEA
    modification-dependent protein catabolic process GO:0019941 IBA
    cellular response to DNA damage stimulus GO:0006974 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 IEA
    endosome membrane GO:0010008 IEA
    desmosome GO:0030057 IEA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 IEA
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 IBA
    nucleus GO:0005634 ISS
    rough endoplasmic reticulum membrane GO:0030867 IEA
    heterochromatin GO:0000792 IEA
 Experiment description of studies that identified UBA1 in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UBA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which UBA1 is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome





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