Gene description for PRDX5
Gene name peroxiredoxin 5
Gene symbol PRDX5
Other names/aliases Prx V
Species Bos taurus
 Database cross references - PRDX5
ExoCarta ExoCarta_282885
Entrez Gene 282885
UniProt Q9BGI1  
 PRDX5 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PRDX5
Molecular Function
    protein dimerization activity GO:0046983 IEA
    peroxidase activity GO:0004601 IEA
    RNA polymerase III regulatory region DNA binding GO:0001016 IEA
    peroxynitrite reductase activity GO:0072541 IEA
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IEA
    receptor binding GO:0005102 IEA
Biological Process
    NADPH oxidation GO:0070995 IEA
    reactive nitrogen species metabolic process GO:2001057 IEA
    negative regulation of transcription from RNA polymerase III promoter GO:0016480 IEA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA
    hydrogen peroxide catabolic process GO:0042744 IEA
    negative regulation of oxidoreductase activity GO:0051354 IEA
    positive regulation of collagen biosynthetic process GO:0032967 IEA
    cellular response to reactive oxygen species GO:0034614 IEA
    regulation of apoptosis involved in tissue homeostasis GO:0060785 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IEA
    peroxisomal matrix GO:0005782 IEA
    nucleus GO:0005634 IEA
    extracellular exosome GO:0070062 IEA
    extracellular space GO:0005615 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    mitochondrion GO:0005739 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified PRDX5 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRDX5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRDX5 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
TP53 Regulates Metabolic Genes IEA Reactome





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