Gene description for SERPINA3-1
Gene name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Gene symbol SERPINA3-1
Other names/aliases SERPINA3
Species Bos taurus
 Database cross references - SERPINA3-1
ExoCarta ExoCarta_286804
Entrez Gene 286804
UniProt Q9TTE1  
 SERPINA3-1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for SERPINA3-1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IDA
    cysteine-type endopeptidase inhibitor activity GO:0004869 IDA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IEA
Subcellular Localization
    cytoplasmic vesicle GO:0031410 IDA
    extracellular space GO:0005615 IDA
    chromaffin granule GO:0042583 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified SERPINA3-1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SERPINA3-1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SERPINA3-1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here