Gene description for GPX4
Gene name glutathione peroxidase 4
Gene symbol GPX4
Other names/aliases PHGPx
Species Bos taurus
 Database cross references - GPX4
ExoCarta ExoCarta_286809
Entrez Gene 286809
UniProt Q9N2J2  
 GPX4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GPX4
Molecular Function
    phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 IEA
    glutathione peroxidase activity GO:0004602 IEA
Biological Process
    multicellular organismal development GO:0007275 IEA
    oxidation-reduction process GO:0055114 IEA
    response to oxidative stress GO:0006979 IEA
Subcellular Localization
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified GPX4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GPX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GPX4 is involved
No pathways found





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