Gene description for CLIC4
Gene name chloride intracellular channel 4
Gene symbol CLIC4
Other names/aliases p64H1
Species Bos taurus
 Database cross references - CLIC4
ExoCarta ExoCarta_286823
Entrez Gene 286823
UniProt Q9XSA7  
 CLIC4 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for CLIC4
Molecular Function
    chloride channel activity GO:0005254 IEA
    voltage-gated ion channel activity GO:0005244 IEA
Biological Process
    angiogenesis GO:0001525 IEA
    fertilization GO:0009566 IEA
    vacuolar acidification GO:0007035 IEA
    chloride transmembrane transport GO:1902476 IEA
    endothelial cell morphogenesis GO:0001886 IEA
    branching morphogenesis of an epithelial tube GO:0048754 IEA
    keratinocyte differentiation GO:0030216 IEA
    regulation of ion transmembrane transport GO:0034765 IEA
    apoptotic process GO:0006915 IEA
    negative regulation of cell migration GO:0030336 IEA
    retina vasculature morphogenesis in camera-type eye GO:0061299 IEA
    multicellular organism growth GO:0035264 IEA
    cellular response to calcium ion GO:0071277 IEA
Subcellular Localization
    chloride channel complex GO:0034707 IEA
    plasma membrane GO:0005886 IEA
    mitochondrion GO:0005739 IEA
    extracellular exosome GO:0070062 IEA
    cell-cell junction GO:0005911 IEA
    centrosome GO:0005813 IEA
    nuclear matrix GO:0016363 IEA
    apical part of cell GO:0045177 IEA
    vacuole GO:0005773 IEA
    microvillus GO:0005902 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    cytosol GO:0005829 IEA
    midbody GO:0030496 IEA
    cell surface GO:0009986 IEA
 Experiment description of studies that identified CLIC4 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLIC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLIC4 is involved
No pathways found





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