Gene description for YWHAB
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Gene symbol YWHAB
Other names/aliases -
Species Bos taurus
 Database cross references - YWHAB
ExoCarta ExoCarta_286863
Vesiclepedia VP_286863
Entrez Gene 286863
UniProt P68250  
 YWHAB identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for YWHAB
Biological Process
    signal transduction GO:0007165 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified YWHAB in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for YWHAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which YWHAB is involved
PathwayEvidenceSource
Activation of BAD and translocation to mitochondria IEA Reactome
Activation of BH3-only proteins IEA Reactome
Adaptive Immune System IEA Reactome
Apoptosis IEA Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex IEA Reactome
FOXO-mediated transcription IEA Reactome
Frs2-mediated activation IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M DNA damage checkpoint IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Immune System IEA Reactome
Intrinsic Pathway for Apoptosis IEA Reactome
MAP2K and MAPK activation IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
Metabolism of RNA IEA Reactome
MTOR signalling IEA Reactome
mTORC1-mediated signalling IEA Reactome
Negative regulation of MAPK pathway IEA Reactome
Programmed Cell Death IEA Reactome
Prolonged ERK activation events IEA Reactome
RAF activation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Rap1 signalling IEA Reactome
Regulation of localization of FOXO transcription factors IEA Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction IEA Reactome
Signaling by Hippo IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signalling to ERKs IEA Reactome
TP53 Regulates Metabolic Genes IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA IEA Reactome





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