Gene description for GOT2
Gene name glutamic-oxaloacetic transaminase 2, mitochondrial
Gene symbol GOT2
Other names/aliases -
Species Bos taurus
 Database cross references - GOT2
ExoCarta ExoCarta_286886
Entrez Gene 286886
UniProt P12344  
 GOT2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for GOT2
Molecular Function
    L-phenylalanine:2-oxoglutarate aminotransferase activity GO:0080130 IEA
    poly(A) RNA binding GO:0044822 IEA
    L-aspartate:2-oxoglutarate aminotransferase activity GO:0004069 ISS
    pyridoxal phosphate binding GO:0030170 IEA
Biological Process
    response to ethanol GO:0045471 IEA
    aspartate metabolic process GO:0006531 ISS
    fatty acid transport GO:0015908 IEA
    glutamate catabolic process to 2-oxoglutarate GO:0019551 IEA
    glutamate catabolic process to aspartate GO:0019550 IEA
    aspartate biosynthetic process GO:0006532 IEA
    aspartate catabolic process GO:0006533 IEA
    oxaloacetate metabolic process GO:0006107 IEA
    glutamate metabolic process GO:0006536 ISS
    2-oxoglutarate metabolic process GO:0006103 ISS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    mitochondrial matrix GO:0005759 IEA
    mitochondrial inner membrane GO:0005743 ISS
    cell surface GO:0009986 ISS
    mitochondrion GO:0005739 ISS
    extracellular exosome GO:0070062 IEA
 Experiment description of studies that identified GOT2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GOT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GOT2 is involved
PathwayEvidenceSource
Amino acid synthesis and interconversion (transamination) IEA Reactome
Gluconeogenesis IEA Reactome





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