Gene description for Stk16
Gene name serine/threonine kinase 16
Gene symbol Stk16
Other names/aliases F52
PKL12
Species Rattus norvegicus
 Database cross references - Stk16
ExoCarta ExoCarta_286927
Entrez Gene 286927
UniProt P57760  
 Stk16 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Stk16
Molecular Function
    protein serine/threonine kinase activity GO:0004674 ISO
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA
    ATP binding GO:0005524 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA
    protein kinase activity GO:0004672 IDA
Biological Process
    protein autophosphorylation GO:0046777 ISO
    regulation of signal transduction GO:0009966 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    protein phosphorylation GO:0006468 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
Subcellular Localization
    membrane GO:0016020 IEA
    Golgi-associated vesicle GO:0005798 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Stk16 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Stk16
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Stk16 is involved
No pathways found





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