Gene description for YWHAZ
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Gene symbol YWHAZ
Other names/aliases -
Species Bos taurus
 Database cross references - YWHAZ
ExoCarta ExoCarta_287022
Entrez Gene 287022
UniProt P63103  
 YWHAZ identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Tracheobronchial cells 19190083    
 Gene ontology annotations for YWHAZ
Molecular Function
    poly(A) RNA binding GO:0044822 IEA
    identical protein binding GO:0042802 IEA
    transcription factor binding GO:0008134 IEA
    protein kinase binding GO:0019901 IEA
    protein domain specific binding GO:0019904 IEA
Biological Process
    establishment of Golgi localization GO:0051683 IEA
    Golgi reassembly GO:0090168 IEA
Subcellular Localization
    focal adhesion GO:0005925 IEA
    blood microparticle GO:0072562 IEA
    extracellular exosome GO:0070062 IEA
    melanosome GO:0042470 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified YWHAZ in exosomes
1
Experiment ID 213
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 34
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD63|MHCI|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19190083    
Organism Homo sapiens
Experiment description Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Authors Kesimer M, Scull M, Brighton B, Demaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK
Journal name FASEB
Publication year 2009
Sample Tracheobronchial cells
Sample name Tracheobronchial epithelial cells
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.16 -1.18 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for YWHAZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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