Gene description for YWHAZ
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Gene symbol YWHAZ
Other names/aliases -
Species Bos taurus
 Database cross references - YWHAZ
ExoCarta ExoCarta_287022
Vesiclepedia VP_287022
Entrez Gene 287022
UniProt P63103  
 YWHAZ identified in sEVs derived from the following tissue/cell type
Milk 23459212    
Tracheobronchial cells 19190083    
 Gene ontology annotations for YWHAZ
Biological Process
    signal transduction GO:0007165 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified YWHAZ in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 34
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
TSG101|CD63|MHCI|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19190083    
Organism Homo sapiens
Experiment description Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Authors "Kesimer M, Scull M, Brighton B, Demaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK"
Journal name FASEB
Publication year 2009
Sample Tracheobronchial cells
Sample name Tracheobronchial epithelial cells
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.16 -1.18 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for YWHAZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP1CC  
Co-fractionation Bos taurus
Affinity Capture-Western Bos taurus
Reconstituted Complex Bos taurus
Affinity Capture-Western Bos taurus
View the network image/svg+xml
 Pathways in which YWHAZ is involved
PathwayEvidenceSource
Activation of BAD and translocation to mitochondria IEA Reactome
Activation of BH3-only proteins IEA Reactome
Adaptive Immune System IEA Reactome
Apoptosis IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
Deactivation of the beta-catenin transactivating complex IEA Reactome
FOXO-mediated transcription IEA Reactome
G2/M Checkpoints IEA Reactome
G2/M DNA damage checkpoint IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
GP1b-IX-V activation signalling IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Intrinsic Pathway for Apoptosis IEA Reactome
KSRP (KHSRP) binds and destabilizes mRNA IEA Reactome
Metabolism of RNA IEA Reactome
NOTCH4 Activation and Transmission of Signal to the Nucleus IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
Programmed Cell Death IEA Reactome
Rap1 signalling IEA Reactome
Regulation of localization of FOXO transcription factors IEA Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate PKNs IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH4 IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by WNT IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
TP53 Regulates Metabolic Genes IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome





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