Gene description for Trap1
Gene name TNF receptor-associated protein 1
Gene symbol Trap1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Trap1
ExoCarta ExoCarta_287069
Vesiclepedia VP_287069
Entrez Gene 287069
UniProt Q5XHZ0  
 Trap1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Trap1
Molecular Function
    RNA binding GO:0003723 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IEA
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 IPI
    protein kinase binding GO:0019901 ISO
    unfolded protein binding GO:0051082 IBA
    unfolded protein binding GO:0051082 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    protein folding GO:0006457 IBA
    protein folding GO:0006457 IEA
    translational attenuation GO:0009386 IEA
    translational attenuation GO:0009386 ISO
    negative regulation of cellular respiration GO:1901856 IEA
    negative regulation of cellular respiration GO:1901856 ISO
    negative regulation of cellular respiration GO:1901856 ISS
    negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:1903751 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial matrix GO:0005759 IEA
    mitochondrial matrix GO:0005759 ISO
    mitochondrial matrix GO:0005759 ISS
    cell periphery GO:0071944 IEA
    cell periphery GO:0071944 ISO
 Experiment description of studies that identified Trap1 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Trap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trap1 is involved
PathwayEvidenceSource
Aerobic respiration and respiratory electron transport IEA Reactome
Citric acid cycle (TCA cycle) IEA Reactome
Metabolism IEA Reactome





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