Gene description for Skp1
Gene name	S-phase kinase-associated protein 1
Gene symbol	Skp1
Other names/aliases	Skp1a
Species	Rattus norvegicus
Database cross references - Skp1
ExoCarta	ExoCarta_287280
Vesiclepedia	VP_287280
Entrez Gene	287280
UniProt	Q6PEC4
Skp1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Skp1

Molecular Function     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 IEA     beta-catenin binding GO:0008013 ISO     protein domain specific binding GO:0019904 ISO     cullin family protein binding GO:0097602 IBA     cullin family protein binding GO:0097602 IEA     cullin family protein binding GO:0097602 ISO     molecular function activator activity GO:0140677 IEA     molecular function activator activity GO:0140677 ISO     ubiquitin ligase complex scaffold activity GO:0160072 IEA     ubiquitin ligase complex scaffold activity GO:0160072 ISO     F-box domain binding GO:1990444 IEA     F-box domain binding GO:1990444 ISO     ubiquitin-like ligase-substrate adaptor activity GO:1990756 IEA     ubiquitin-like ligase-substrate adaptor activity GO:1990756 ISO Biological Process     protein polyubiquitination GO:0000209 ISO     chromatin remodeling GO:0006338 IEA     chromatin remodeling GO:0006338 ISO     ubiquitin-dependent protein catabolic process GO:0006511 IEA     protein monoubiquitination GO:0006513 IEA     protein monoubiquitination GO:0006513 ISO     protein ubiquitination GO:0016567 IEA     protein ubiquitination GO:0016567 ISO     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IBA     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IEA     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISO     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISS     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO     maintenance of protein location in nucleus GO:0051457 IEA     maintenance of protein location in nucleus GO:0051457 ISO     protein K48-linked ubiquitination GO:0070936 IEA     protein K48-linked ubiquitination GO:0070936 ISO     protein K48-linked ubiquitination GO:0070936 ISO     positive regulation of ubiquitin protein ligase activity GO:1904668 ISO Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     gap junction GO:0005921 IDA     SCF ubiquitin ligase complex GO:0019005 IEA     SCF ubiquitin ligase complex GO:0019005 ISO     SCF ubiquitin ligase complex GO:0019005 ISS     Cul7-RING ubiquitin ligase complex GO:0031467 IEA     Cul7-RING ubiquitin ligase complex GO:0031467 ISO     Cul7-RING ubiquitin ligase complex GO:0031467 ISS     PcG protein complex GO:0031519 IEA     PcG protein complex GO:0031519 ISO