Gene description for Dhrs7b
Gene name dehydrogenase/reductase (SDR family) member 7B
Gene symbol Dhrs7b
Other names/aliases RGD1311243
Species Rattus norvegicus
 Database cross references - Dhrs7b
ExoCarta ExoCarta_287380
Vesiclepedia VP_287380
Entrez Gene 287380
UniProt Q5RJY4  
 Dhrs7b identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Dhrs7b
Molecular Function
    transcription corepressor activity GO:0003714 IEA
    transcription corepressor activity GO:0003714 ISO
    oxidoreductase activity GO:0016491 IEA
    DNA-binding transcription factor binding GO:0140297 IEA
    DNA-binding transcription factor binding GO:0140297 ISO
Biological Process
    regulation of DNA-templated transcription GO:0006355 ISO
    phosphatidylcholine biosynthetic process GO:0006656 IEA
    phosphatidylcholine biosynthetic process GO:0006656 ISO
    inflammatory response GO:0006954 IEA
    inflammatory response GO:0006954 ISO
    ether lipid biosynthetic process GO:0008611 IEA
    ether lipid biosynthetic process GO:0008611 ISO
    regulation of gene expression GO:0010468 ISO
    neutrophil differentiation GO:0030223 IEA
    neutrophil differentiation GO:0030223 ISO
    negative regulation of DNA-templated transcription GO:0045892 IEA
    brown fat cell differentiation GO:0050873 IEA
    brown fat cell differentiation GO:0050873 ISO
    adipose tissue development GO:0060612 IEA
    adipose tissue development GO:0060612 ISO
    regulation of cold-induced thermogenesis GO:0120161 IEA
    regulation of cold-induced thermogenesis GO:0120161 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    transcription regulator complex GO:0005667 IEA
    transcription regulator complex GO:0005667 ISO
    peroxisome GO:0005777 IEA
    peroxisome GO:0005777 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IBA
    membrane GO:0016020 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Dhrs7b in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Dhrs7b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dhrs7b is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of lipids IEA Reactome
Plasmalogen biosynthesis IEA Reactome
Wax and plasmalogen biosynthesis IEA Reactome





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