Gene description for Umps
Gene name uridine monophosphate synthetase
Gene symbol Umps
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Umps
ExoCarta ExoCarta_288051
Vesiclepedia VP_288051
Entrez Gene 288051
 Umps identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Umps
Molecular Function
    orotate phosphoribosyltransferase activity GO:0004588 IDA
    orotate phosphoribosyltransferase activity GO:0004588 ISO
    orotidine-5'-phosphate decarboxylase activity GO:0004590 IDA
    orotidine-5'-phosphate decarboxylase activity GO:0004590 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    UMP biosynthetic process GO:0006222 IDA
    UMP biosynthetic process GO:0006222 ISO
    UDP biosynthetic process GO:0006225 ISO
    female pregnancy GO:0007565 IEP
    lactation GO:0007595 IEP
    'de novo' UMP biosynthetic process GO:0044205 IEA
    'de novo' UMP biosynthetic process GO:0044205 ISO
    cellular response to xenobiotic stimulus GO:0071466 IEP
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Umps in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Umps
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Umps is involved
No pathways found





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