Gene description for Tmem120a
Gene name transmembrane protein 120A
Gene symbol Tmem120a
Other names/aliases RGD1311474
Tmpit
Species Rattus norvegicus
 Database cross references - Tmem120a
ExoCarta ExoCarta_288591
Vesiclepedia VP_288591
Entrez Gene 288591
UniProt Q5HZE2  
 Tmem120a identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tmem120a
Molecular Function
    monoatomic ion channel activity GO:0005216 IEA
    monoatomic ion channel activity GO:0005216 ISO
    monoatomic ion channel activity GO:0005216 ISO
    monoatomic ion channel activity GO:0005216 ISS
    coenzyme A binding GO:0120225 ISO
    coenzyme A binding GO:0120225 ISS
Biological Process
    biological_process GO:0008150 ND
    monoatomic ion transmembrane transport GO:0034220 IEA
    monoatomic ion transmembrane transport GO:0034220 ISO
    monoatomic ion transmembrane transport GO:0034220 ISS
    fat cell differentiation GO:0045444 IBA
    fat cell differentiation GO:0045444 IEA
    fat cell differentiation GO:0045444 ISO
    fat cell differentiation GO:0045444 ISS
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IEA
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 ISO
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 ISS
    protein homooligomerization GO:0051260 IEA
    protein homooligomerization GO:0051260 ISO
    protein homooligomerization GO:0051260 ISS
    protein heterooligomerization GO:0051291 IEA
    protein heterooligomerization GO:0051291 ISO
    protein heterooligomerization GO:0051291 ISS
    antiviral innate immune response GO:0140374 ISO
Subcellular Localization
    nuclear inner membrane GO:0005637 IEA
    endoplasmic reticulum GO:0005783 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IBA
 Experiment description of studies that identified Tmem120a in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tmem120a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmem120a is involved
No pathways found





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