Gene description for Tesc
Gene name tescalcin
Gene symbol Tesc
Other names/aliases RGD1566317
Species Rattus norvegicus
 Database cross references - Tesc
ExoCarta ExoCarta_288689
Entrez Gene 288689
 Tesc identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Tesc
Molecular Function
    phosphatase inhibitor activity GO:0019212 ISO
    calcium ion binding GO:0005509 ISS
    magnesium ion binding GO:0000287 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    male gonad development GO:0008584 IEA
    positive regulation of megakaryocyte differentiation GO:0045654 ISS
    positive regulation of granulocyte differentiation GO:0030854 ISO
    protein stabilization GO:0050821 ISO
    negative regulation of catalytic activity GO:0043086 ISO
    negative regulation of cell proliferation GO:0008285 ISS
    cellular response to retinoic acid GO:0071300 ISO
    positive regulation of gene expression GO:0010628 ISS
    positive regulation of transcription, DNA-templated GO:0045893 ISS
    protein targeting to plasma membrane GO:0072661 ISO
    regulation of cell adhesion mediated by integrin GO:0033628 ISS
    megakaryocyte development GO:0035855 ISO
    positive regulation of sodium:proton antiporter activity GO:0032417 ISO
    megakaryocyte differentiation GO:0030219 IEA
    protein maturation GO:0051604 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    lamellipodium GO:0030027 ISS
    ruffle GO:0001726 ISO
    nucleus GO:0005634 ISS
    plasma membrane GO:0005886 ISS
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Tesc in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Tesc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tesc is involved
No pathways found





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