Gene description for Hmcn1
Gene name hemicentin 1
Gene symbol Hmcn1
Other names/aliases RGD1564772
Species Rattus norvegicus
 Database cross references - Hmcn1
ExoCarta ExoCarta_289094
Vesiclepedia VP_289094
Entrez Gene 289094
 Hmcn1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Hmcn1
Molecular Function
    calcium ion binding GO:0005509 IEA
    axon guidance receptor activity GO:0008046 IBA
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
    axon guidance GO:0007411 IEA
    response to bacterium GO:0009617 ISO
    actin cytoskeleton organization GO:0030036 ISO
    synapse organization GO:0050808 IBA
    basement membrane organization GO:0071711 ISO
Subcellular Localization
    extracellular region GO:0005576 ISO
    basement membrane GO:0005604 ISO
    cytoplasm GO:0005737 ISO
    plasma membrane GO:0005886 IBA
    muscle tendon junction GO:0005927 ISO
    cell cortex GO:0005938 ISO
    cell junction GO:0030054 ISO
    axon GO:0030424 IBA
    neuronal cell body GO:0043025 IBA
 Experiment description of studies that identified Hmcn1 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Hmcn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hmcn1 is involved
No pathways found





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