Gene description for Nvl
Gene name nuclear VCP-like
Gene symbol Nvl
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Nvl
ExoCarta ExoCarta_289323
Vesiclepedia VP_289323
Entrez Gene 289323
 Nvl identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Nvl
Molecular Function
    ATP binding GO:0005524 ISO
    ATP hydrolysis activity GO:0016887 IBA
    preribosome binding GO:1990275 IBA
    preribosome binding GO:1990275 ISO
Biological Process
    rRNA processing GO:0006364 ISO
    positive regulation of telomere maintenance GO:0032206 ISO
    ribosome biogenesis GO:0042254 IBA
    ribosome biogenesis GO:0042254 ISO
    ribosomal large subunit biogenesis GO:0042273 ISO
    regulation of protein localization to nucleolus GO:1904749 ISO
    telomerase holoenzyme complex assembly GO:1905323 ISO
Subcellular Localization
    nuclear exosome (RNase complex) GO:0000176 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    telomerase holoenzyme complex GO:0005697 ISO
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Nvl in sEVs
1
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [MALDI TOF]
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Nvl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nvl is involved
No pathways found





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