ExoCarta: Gene summary

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Gene description for Slc30a10
Gene name	solute carrier family 30, member 10
Gene symbol	Slc30a10
Other names/aliases	RGD1305098
Species	Rattus norvegicus
Database cross references - Slc30a10
ExoCarta	ExoCarta_289353
Vesiclepedia	VP_289353
Entrez Gene	289353
Slc30a10 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Slc30a10

Molecular Function
	manganese ion transmembrane transporter activity	GO:0005384	ISO
	zinc ion transmembrane transporter activity	GO:0005385	IBA
	zinc ion transmembrane transporter activity	GO:0005385	ISO
	zinc ion transmembrane transporter activity	GO:0005385	ISO
	calcium:manganese antiporter activity	GO:0140983	ISO
Biological Process
	manganese ion transport	GO:0006828	IBA
	manganese ion transport	GO:0006828	ISO
	intracellular copper ion homeostasis	GO:0006878	ISO
	intracellular zinc ion homeostasis	GO:0006882	IBA
	intracellular zinc ion homeostasis	GO:0006882	ISO
	intracellular zinc ion homeostasis	GO:0006882	ISO
	epidermal growth factor receptor signaling pathway	GO:0007173	ISO
	detoxification of zinc ion	GO:0010312	IBA
	intracellular manganese ion homeostasis	GO:0030026	ISO
	manganese ion homeostasis	GO:0055071	ISO
	zinc ion import into organelle	GO:0062111	ISO
	positive regulation of ERK1 and ERK2 cascade	GO:0070374	ISO
	zinc ion transmembrane transport	GO:0071577	IBA
	manganese ion export across plasma membrane	GO:0140048	ISO
	cellular response to angiotensin	GO:1904385	ISO
Subcellular Localization
	early endosome	GO:0005769	ISO
	Golgi apparatus	GO:0005794	ISO
	plasma membrane	GO:0005886	ISO
	synaptic vesicle	GO:0008021	ISO
	membrane	GO:0016020	IBA
	early endosome membrane	GO:0031901	ISO
	recycling endosome	GO:0055037	ISO
	recycling endosome membrane	GO:0055038	ISO

Experiment description of studies that identified Slc30a10 in sEVs

Experiment ID

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|HSP90\|HSC70\|MHCI	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

"Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D2 Rep 2

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.16-1.21 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting