Gene description for Tmed5
Gene name transmembrane emp24 protein transport domain containing 5
Gene symbol Tmed5
Other names/aliases LRRG00120
Species Rattus norvegicus
 Database cross references - Tmed5
ExoCarta ExoCarta_289883
Entrez Gene 289883
UniProt Q6AXN3  
 Tmed5 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Tmed5
Biological Process
    protein transport GO:0015031 IEA
    Golgi ribbon formation GO:0090161 ISS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum exit site GO:0070971 ISS
    cis-Golgi network GO:0005801 ISS
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
    Golgi apparatus GO:0005794 IEA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISS
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified Tmed5 in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Tmed5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmed5 is involved
PathwayEvidenceSource
WNT ligand biogenesis and trafficking IEA Reactome





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