Gene description for Gmds
Gene name GDP-mannose 4, 6-dehydratase
Gene symbol Gmds
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gmds
ExoCarta ExoCarta_291095
Vesiclepedia VP_291095
Entrez Gene 291095
 Gmds identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Gmds
Molecular Function
    GDP-mannose 4,6-dehydratase activity GO:0008446 IBA
    GDP-mannose 4,6-dehydratase activity GO:0008446 ISO
    GDP-mannose 4,6-dehydratase activity GO:0008446 ISS
    identical protein binding GO:0042802 ISO
    NADP+ binding GO:0070401 ISO
    NADP+ binding GO:0070401 ISS
Biological Process
    Notch signaling pathway GO:0007219 ISS
    GDP-mannose metabolic process GO:0019673 ISO
    GDP-mannose metabolic process GO:0019673 ISS
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 IBA
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 IEA
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 ISO
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 ISS
Subcellular Localization
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Gmds in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Gmds
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gmds is involved
No pathways found





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