Gene description for Hist1h1a
Gene name histone cluster 1, H1a
Gene symbol Hist1h1a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Hist1h1a
ExoCarta ExoCarta_291145
Vesiclepedia VP_291145
Entrez Gene 291145
UniProt D4A3K5  
 Hist1h1a identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Hist1h1a
Molecular Function
    DNA binding GO:0003677 ISO
    double-stranded DNA binding GO:0003690 IBA
    heparin binding GO:0008201 ISO
    structural constituent of chromatin GO:0030527 IEA
    chromatin DNA binding GO:0031490 ISO
    nucleosomal DNA binding GO:0031492 IBA
Biological Process
    nucleosome assembly GO:0006334 IEA
    spermatogenesis GO:0007283 IBA
    spermatogenesis GO:0007283 ISO
    chromosome condensation GO:0030261 IBA
    negative regulation of DNA recombination GO:0045910 IBA
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
Subcellular Localization
    chromatin GO:0000785 ISO
    nucleosome GO:0000786 IEA
    euchromatin GO:0000791 IBA
    euchromatin GO:0000791 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    cell surface GO:0009986 ISO
    vesicle GO:0031982 ISO
 Experiment description of studies that identified Hist1h1a in sEVs
1
Experiment ID 96
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Hist1h1a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cdk2  
Biochemical Activity Rattus norvegicus
2 Ccne1  
Biochemical Activity Rattus norvegicus
3 Ccna1  
Biochemical Activity Rattus norvegicus
4 Prkca  
Biochemical Activity Rattus norvegicus
5 Prkcd  
Biochemical Activity Rattus norvegicus
6 Cdk1  
Biochemical Activity Rattus norvegicus
7 Prkcb  
Biochemical Activity Rattus norvegicus
8 Prkce  
Biochemical Activity Rattus norvegicus
View the network image/svg+xml
 Pathways in which Hist1h1a is involved
PathwayEvidenceSource
Apoptosis IEA Reactome
Apoptosis induced DNA fragmentation IEA Reactome
Apoptotic execution phase IEA Reactome
Programmed Cell Death IEA Reactome





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