Gene description for Vtn
Gene name vitronectin
Gene symbol Vtn
Other names/aliases Aa1018
Vn
Species Rattus norvegicus
 Database cross references - Vtn
ExoCarta ExoCarta_29169
Vesiclepedia VP_29169
Entrez Gene 29169
 Vtn identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Vtn
Molecular Function
    scavenger receptor activity GO:0005044 IEA
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 ISO
    collagen binding GO:0005518 IDA
    heparin binding GO:0008201 IDA
    polysaccharide binding GO:0030247 IEA
    identical protein binding GO:0042802 IDA
    extracellular matrix binding GO:0050840 IBA
    extracellular matrix binding GO:0050840 ISO
Biological Process
    immune response GO:0006955 IEA
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 ISO
    cell-matrix adhesion GO:0007160 ISO
    positive regulation of cell-substrate adhesion GO:0010811 ISO
    negative regulation of endopeptidase activity GO:0010951 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    vesicle-mediated transport GO:0016192 IEA
    cell migration GO:0016477 ISO
    regulation of cell adhesion GO:0030155 ISO
    extracellular matrix organization GO:0030198 ISO
    cell adhesion mediated by integrin GO:0033627 IBA
    cell adhesion mediated by integrin GO:0033627 ISO
    endodermal cell differentiation GO:0035987 ISO
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
    oligodendrocyte differentiation GO:0048709 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    protein polymerization GO:0051258 IDA
    smooth muscle cell-matrix adhesion GO:0061302 ISO
    liver regeneration GO:0097421 IDA
Subcellular Localization
    basement membrane GO:0005604 IDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    endoplasmic reticulum GO:0005783 ISO
    Golgi lumen GO:0005796 IDA
    extracellular matrix GO:0031012 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    rough endoplasmic reticulum lumen GO:0048237 IDA
    collagen-containing extracellular matrix GO:0062023 IBA
    collagen-containing extracellular matrix GO:0062023 IDA
    collagen-containing extracellular matrix GO:0062023 ISO
    protein complex involved in cell-matrix adhesion GO:0098637 ISO
    peptidase inhibitor complex GO:1904090 ISO
 Experiment description of studies that identified Vtn in sEVs
1
Experiment ID 90
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70|HSP90|TSG101|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Vtn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vtn is involved
No pathways found





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