Gene description for Iws1
Gene name IWS1 homolog (S. cerevisiae)
Gene symbol Iws1
Other names/aliases RGD1304762
Species Rattus norvegicus
 Database cross references - Iws1
ExoCarta ExoCarta_291705
Vesiclepedia VP_291705
Entrez Gene 291705
UniProt Q3SWT4  
 Iws1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Iws1
Biological Process
    chromatin remodeling GO:0006338 ISO
    chromatin remodeling GO:0006338 ISS
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
    regulation of mRNA export from nucleus GO:0010793 IEA
    regulation of mRNA export from nucleus GO:0010793 ISO
    regulation of mRNA export from nucleus GO:0010793 ISS
    poly(A)+ mRNA export from nucleus GO:0016973 IBA
    regulation of mRNA processing GO:0050684 IEA
    regulation of mRNA processing GO:0050684 ISO
    regulation of mRNA processing GO:0050684 ISS
    transcription elongation-coupled chromatin remodeling GO:0140673 IEA
    transcription elongation-coupled chromatin remodeling GO:0140673 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Iws1 in sEVs
1
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Iws1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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