Gene description for Iws1
Gene name IWS1 homolog (S. cerevisiae)
Gene symbol Iws1
Other names/aliases RGD1304762
Species Rattus norvegicus
 Database cross references - Iws1
ExoCarta ExoCarta_291705
Entrez Gene 291705
UniProt Q3SWT4  
 Iws1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Iws1
Molecular Function
    DNA binding GO:0003677 IEA
Biological Process
    mRNA transport GO:0051028 IEA
    RNA splicing GO:0008380 IEA
    regulation of histone H4 acetylation GO:0090239 ISS
    transcription, DNA-templated GO:0006351 IEA
    regulation of mRNA processing GO:0050684 ISS
    mRNA processing GO:0006397 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of mRNA export from nucleus GO:0010793 ISS
    regulation of histone H3-K36 trimethylation GO:2001253 ISS
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Iws1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Iws1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Iws1 is involved
No pathways found





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