Gene description for Cd36
Gene name CD36 molecule (thrombospondin receptor)
Gene symbol Cd36
Other names/aliases Fat
Species Rattus norvegicus
 Database cross references - Cd36
ExoCarta ExoCarta_29184
Entrez Gene 29184
 Cd36 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Cd36
Molecular Function
    high-density lipoprotein particle binding GO:0008035 ISO
    lipoteichoic acid receptor activity GO:0070892 ISO
    lipoprotein particle binding GO:0071813 ISO
    low-density lipoprotein receptor activity GO:0005041 ISO
    thrombospondin receptor activity GO:0070053 IDA
    protein binding GO:0005515 IPI
    oleic acid binding GO:0070538 IDA
    lipid binding GO:0008289 ISO
    low-density lipoprotein particle binding GO:0030169 ISO
    transforming growth factor beta binding GO:0050431 IDA
Biological Process
    cGMP-mediated signaling GO:0019934 ISO
    positive regulation of cholesterol storage GO:0010886 ISO
    cellular response to hydroperoxide GO:0071447 ISO
    response to estradiol GO:0032355 IEP
    response to growth hormone GO:0060416 IEP
    negative regulation of transcription factor import into nucleus GO:0042992 ISO
    positive regulation of cytokine secretion GO:0050715 IMP
    cholesterol transport GO:0030301 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    pattern recognition receptor signaling pathway GO:0002221 ISO
    cell surface receptor signaling pathway GO:0007166 ISO
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
    lipid storage GO:0019915 ISO
    response to mechanical stimulus GO:0009612 IMP
    fatty acid transport GO:0015908 IMP
    long-chain fatty acid metabolic process GO:0001676 IMP
    positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO
    positive regulation of MAPK cascade GO:0043410 ISO
    lipoprotein transport GO:0042953 ISO
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
    negative regulation of gene expression GO:0010629 ISO
    cellular response to bacterial lipopeptide GO:0071221 ISO
    positive regulation of blood coagulation GO:0030194 ISO
    phagocytosis, recognition GO:0006910 ISO
    cellular response to lipopolysaccharide GO:0071222 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    plasma membrane long-chain fatty acid transport GO:0015911 ISO
    cellular response to lipoteichoic acid GO:0071223 ISO
    low-density lipoprotein particle clearance GO:0034383 ISO
    regulation of removal of superoxide radicals GO:2000121 ISO
    low-density lipoprotein particle mediated signaling GO:0055096 ISO
    fatty acid oxidation GO:0019395 IMP
    defense response to Gram-positive bacterium GO:0050830 ISO
    long-chain fatty acid transport GO:0015909 IMP
    positive regulation of macrophage cytokine production GO:0060907 ISO
    response to nutrient GO:0007584 IEP
    digestive tract development GO:0048565 IEP
    plasma lipoprotein particle clearance GO:0034381 ISO
    cellular response to insulin stimulus GO:0032869 IEP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    negative regulation of angiogenesis GO:0016525 IMP
    response to drug GO:0042493 IEP
    cell adhesion GO:0007155 IEA
    negative regulation of systemic arterial blood pressure GO:0003085 IMP
    apoptotic cell clearance GO:0043277 ISO
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    nitric oxide mediated signal transduction GO:0007263 ISO
    long-chain fatty acid import GO:0044539 ISO
    fatty acid metabolic process GO:0006631 IMP
    positive regulation of interleukin-6 production GO:0032755 ISO
    positive regulation of blood microparticle formation GO:2000334 ISO
    positive regulation of interleukin-12 production GO:0032735 ISO
    response to activity GO:0014823 IEP
    signal transduction GO:0007165 IDA
    negative regulation of growth of symbiont in host GO:0044130 ISO
    triglyceride metabolic process GO:0006641 IMP
Subcellular Localization
    sarcolemma GO:0042383 IDA
    integral component of membrane GO:0016021 IEA
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    apical part of cell GO:0045177 IDA
    mitochondrion GO:0005739 IDA
    protein complex GO:0043234 IDA
    endoplasmic reticulum GO:0005783 IDA
    membrane raft GO:0045121 ISO
    intracellular GO:0005622 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    Golgi apparatus GO:0005794 ISO
    external side of plasma membrane GO:0009897 ISO
    caveola GO:0005901 IDA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Cd36 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Cd36
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd36 is involved
No pathways found





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