Gene description for Cd36
Gene name CD36 molecule (thrombospondin receptor)
Gene symbol Cd36
Other names/aliases Fat
Species Rattus norvegicus
 Database cross references - Cd36
ExoCarta ExoCarta_29184
Vesiclepedia VP_29184
Entrez Gene 29184
 Cd36 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Cd36
Molecular Function
    amyloid-beta binding GO:0001540 IEA
    amyloid-beta binding GO:0001540 ISO
    low-density lipoprotein particle receptor activity GO:0005041 IBA
    low-density lipoprotein particle receptor activity GO:0005041 IEA
    low-density lipoprotein particle receptor activity GO:0005041 ISO
    scavenger receptor activity GO:0005044 IBA
    scavenger receptor activity GO:0005044 IEA
    scavenger receptor activity GO:0005044 IMP
    scavenger receptor activity GO:0005044 ISO
    long-chain fatty acid transmembrane transporter activity GO:0005324 ISO
    protein binding GO:0005515 IPI
    high-density lipoprotein particle binding GO:0008035 IEA
    high-density lipoprotein particle binding GO:0008035 ISO
    lipid binding GO:0008289 IEA
    lipid binding GO:0008289 ISO
    short-chain fatty acid transmembrane transporter activity GO:0015636 IEA
    short-chain fatty acid transmembrane transporter activity GO:0015636 ISO
    low-density lipoprotein particle binding GO:0030169 IBA
    low-density lipoprotein particle binding GO:0030169 IEA
    low-density lipoprotein particle binding GO:0030169 ISO
    Toll-like receptor binding GO:0035325 IEA
    Toll-like receptor binding GO:0035325 ISO
    cargo receptor activity GO:0038024 ISO
    protein-containing complex binding GO:0044877 ISO
    transforming growth factor beta binding GO:0050431 IDA
    thrombospondin receptor activity GO:0070053 IDA
    thrombospondin receptor activity GO:0070053 IEA
    thrombospondin receptor activity GO:0070053 ISO
    oleic acid binding GO:0070538 IDA
    lipoteichoic acid immune receptor activity GO:0070892 IEA
    lipoteichoic acid immune receptor activity GO:0070892 ISO
    lipoprotein particle binding GO:0071813 ISO
    oxidised low-density lipoprotein particle receptor activity GO:0150025 IEA
    oxidised low-density lipoprotein particle receptor activity GO:0150025 ISO
    oleate transmembrane transporter activity GO:1901480 IEA
    oleate transmembrane transporter activity GO:1901480 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    MAPK cascade GO:0000165 IEA
    MAPK cascade GO:0000165 ISO
    long-chain fatty acid metabolic process GO:0001676 IMP
    positive regulation of cytokine production GO:0001819 IMP
    maternal placenta development GO:0001893 IEP
    positive regulation of cell-matrix adhesion GO:0001954 IEA
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    negative regulation of systemic arterial blood pressure GO:0003085 IMP
    fatty acid metabolic process GO:0006631 IDA
    fatty acid metabolic process GO:0006631 IMP
    triglyceride metabolic process GO:0006641 IMP
    lipid transport GO:0006869 IEA
    receptor-mediated endocytosis GO:0006898 IBA
    receptor-mediated endocytosis GO:0006898 IMP
    receptor-mediated endocytosis GO:0006898 ISO
    phagocytosis, recognition GO:0006910 IEA
    phagocytosis, recognition GO:0006910 ISO
    cell adhesion GO:0007155 IEA
    cell surface receptor signaling pathway GO:0007166 IEA
    cell surface receptor signaling pathway GO:0007166 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISS
    response to nutrient GO:0007584 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    response to mechanical stimulus GO:0009612 IMP
    response to bacterium GO:0009617 ISO
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of macrophage derived foam cell differentiation GO:0010744 IEA
    positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO
    positive regulation of cholesterol storage GO:0010886 IEA
    positive regulation of cholesterol storage GO:0010886 ISO
    response to activity GO:0014823 IEP
    fatty acid transport GO:0015908 IDA
    fatty acid transport GO:0015908 IEP
    fatty acid transport GO:0015908 IMP
    fatty acid transport GO:0015908 ISO
    long-chain fatty acid transport GO:0015909 IMP
    long-chain fatty acid transport GO:0015909 ISO
    long-chain fatty acid import across plasma membrane GO:0015911 IEA
    long-chain fatty acid import across plasma membrane GO:0015911 ISO
    short-chain fatty acid transport GO:0015912 IEA
    short-chain fatty acid transport GO:0015912 ISO
    negative regulation of angiogenesis GO:0016525 IEA
    negative regulation of angiogenesis GO:0016525 IMP
    negative regulation of angiogenesis GO:0016525 ISO
    fatty acid oxidation GO:0019395 IMP
    lipid storage GO:0019915 IBA
    lipid storage GO:0019915 IEA
    lipid storage GO:0019915 ISO
    cGMP-mediated signaling GO:0019934 ISO
    positive regulation of blood coagulation GO:0030194 IEA
    positive regulation of blood coagulation GO:0030194 ISO
    intestinal cholesterol absorption GO:0030299 IEA
    intestinal cholesterol absorption GO:0030299 ISO
    intestinal cholesterol absorption GO:0030299 ISS
    cholesterol transport GO:0030301 ISO
    receptor internalization GO:0031623 IEA
    receptor internalization GO:0031623 ISO
    receptor internalization GO:0031623 ISS
    response to estradiol GO:0032355 IEP
    positive regulation of interleukin-1 beta production GO:0032731 IEA
    positive regulation of interleukin-1 beta production GO:0032731 ISO
    positive regulation of interleukin-1 beta production GO:0032731 ISS
    positive regulation of interleukin-12 production GO:0032735 IEA
    positive regulation of interleukin-12 production GO:0032735 ISO
    positive regulation of interleukin-6 production GO:0032755 IEA
    positive regulation of interleukin-6 production GO:0032755 ISO
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    cellular response to insulin stimulus GO:0032869 IEP
    response to vitamin B3 GO:0033552 IEP
    response to lipid GO:0033993 IMP
    response to lipid GO:0033993 ISO
    regulation of toll-like receptor signaling pathway GO:0034121 IEA
    regulation of toll-like receptor signaling pathway GO:0034121 ISO
    triglyceride transport GO:0034197 IEA
    triglyceride transport GO:0034197 ISO
    triglyceride transport GO:0034197 ISS
    plasma lipoprotein particle clearance GO:0034381 ISO
    low-density lipoprotein particle clearance GO:0034383 IBA
    low-density lipoprotein particle clearance GO:0034383 IEA
    low-density lipoprotein particle clearance GO:0034383 ISO
    cellular response to oxidative stress GO:0034599 ISO
    response to stilbenoid GO:0035634 IEA
    response to stilbenoid GO:0035634 ISO
    nitric oxide-cGMP-mediated signaling GO:0038060 IEA
    nitric oxide-cGMP-mediated signaling GO:0038060 ISO
    negative regulation of protein import into nucleus GO:0042308 IEA
    negative regulation of protein import into nucleus GO:0042308 ISO
    eating behavior GO:0042755 IMP
    lipoprotein transport GO:0042953 IBA
    lipoprotein transport GO:0042953 IEA
    lipoprotein transport GO:0042953 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    regulation of protein-containing complex assembly GO:0043254 ISO
    apoptotic cell clearance GO:0043277 IEA
    apoptotic cell clearance GO:0043277 ISO
    positive regulation of MAPK cascade GO:0043410 ISO
    long-chain fatty acid import into cell GO:0044539 IBA
    long-chain fatty acid import into cell GO:0044539 ISO
    long-chain fatty acid import into cell GO:0044539 ISS
    positive regulation of nitric oxide biosynthetic process GO:0045429 IEA
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISO
    positive regulation of glycogen biosynthetic process GO:0045725 IDA
    digestive tract development GO:0048565 IEP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    positive regulation of phagocytosis GO:0050766 IMP
    defense response to Gram-positive bacterium GO:0050830 IEA
    defense response to Gram-positive bacterium GO:0050830 ISO
    intestinal absorption GO:0050892 ISO
    intestinal absorption GO:0050892 ISS
    sensory perception of taste GO:0050909 IEA
    sensory perception of taste GO:0050909 ISO
    sensory perception of taste GO:0050909 ISS
    low-density lipoprotein particle mediated signaling GO:0055096 IEA
    low-density lipoprotein particle mediated signaling GO:0055096 ISO
    positive regulation of phagocytosis, engulfment GO:0060100 IEA
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
    response to growth hormone GO:0060416 IEP
    positive regulation of macrophage cytokine production GO:0060907 IEA
    positive regulation of macrophage cytokine production GO:0060907 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    cholesterol import GO:0070508 IEA
    cholesterol import GO:0070508 ISO
    cholesterol import GO:0070508 ISS
    response to fatty acid GO:0070542 IDA
    response to fatty acid GO:0070542 IMP
    response to fatty acid GO:0070542 ISO
    response to linoleic acid GO:0070543 IEA
    response to linoleic acid GO:0070543 ISO
    response to linoleic acid GO:0070543 ISS
    cellular response to bacterial lipopeptide GO:0071221 ISO
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to lipoteichoic acid GO:0071223 IEA
    cellular response to lipoteichoic acid GO:0071223 ISO
    cellular response to low-density lipoprotein particle stimulus GO:0071404 ISO
    cellular response to low-density lipoprotein particle stimulus GO:0071404 ISS
    cellular response to hydroperoxide GO:0071447 IEA
    cellular response to hydroperoxide GO:0071447 ISO
    cellular response to diacyl bacterial lipopeptide GO:0071726 IEA
    cellular response to diacyl bacterial lipopeptide GO:0071726 ISO
    cellular response to diacyl bacterial lipopeptide GO:0071726 ISS
    positive regulation of triglyceride metabolic process GO:0090208 IDA
    energy homeostasis GO:0097009 IEA
    energy homeostasis GO:0097009 IMP
    energy homeostasis GO:0097009 ISO
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IEP
    regulation of action potential GO:0098900 IEA
    regulation of action potential GO:0098900 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 IEA
    cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 ISO
    oxidised low-density lipoprotein particle clearance GO:0150024 IEA
    oxidised low-density lipoprotein particle clearance GO:0150024 ISO
    amyloid-beta clearance by cellular catabolic process GO:0150094 IBA
    amyloid-beta clearance by cellular catabolic process GO:0150094 IEA
    amyloid-beta clearance by cellular catabolic process GO:0150094 IMP
    amyloid-beta clearance by cellular catabolic process GO:0150094 ISO
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IEA
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISO
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 ISS
    positive regulation of reactive oxygen species biosynthetic process GO:1903428 IEA
    positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISO
    cellular response to amyloid-beta GO:1904646 IEA
    cellular response to amyloid-beta GO:1904646 ISO
    amyloid fibril formation GO:1990000 IEA
    amyloid fibril formation GO:1990000 ISO
    amyloid fibril formation GO:1990000 ISS
    lipid transport across blood-brain barrier GO:1990379 IEA
    lipid transport across blood-brain barrier GO:1990379 ISO
    regulation of removal of superoxide radicals GO:2000121 IEA
    regulation of removal of superoxide radicals GO:2000121 ISO
    positive regulation of blood microparticle formation GO:2000334 IEA
    positive regulation of blood microparticle formation GO:2000334 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    plasma membrane GO:0005886 ISO
    caveola GO:0005901 IBA
    caveola GO:0005901 IDA
    external side of plasma membrane GO:0009897 IEA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 ISO
    apical plasma membrane GO:0016324 IEA
    brush border membrane GO:0031526 IDA
    brush border membrane GO:0031526 IEA
    brush border membrane GO:0031526 ISO
    protein-containing complex GO:0032991 IDA
    sarcolemma GO:0042383 IDA
    receptor complex GO:0043235 IEA
    receptor complex GO:0043235 ISO
    membrane raft GO:0045121 IEA
    membrane raft GO:0045121 ISO
    apical part of cell GO:0045177 IDA
    apical part of cell GO:0045177 ISO
    cell periphery GO:0071944 ISO
 Experiment description of studies that identified Cd36 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Cd36
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd36 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here