Gene description for Cd36
Gene name CD36 molecule (thrombospondin receptor)
Gene symbol Cd36
Other names/aliases Fat
Species Rattus norvegicus
 Database cross references - Cd36
ExoCarta ExoCarta_29184
Entrez Gene 29184
 Cd36 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Cd36
Molecular Function
    high-density lipoprotein particle binding GO:0008035 ISO
    lipoteichoic acid receptor activity GO:0070892 ISO
    lipoprotein particle binding GO:0071813 ISO
    low-density lipoprotein receptor activity GO:0005041 ISO
    thrombospondin receptor activity GO:0070053 IDA
    protein binding GO:0005515 IPI
    oleic acid binding GO:0070538 IDA
    lipid binding GO:0008289 ISO
    low-density lipoprotein particle binding GO:0030169 ISO
    transforming growth factor beta binding GO:0050431 IDA
Biological Process
    cGMP-mediated signaling GO:0019934 ISO
    positive regulation of cholesterol storage GO:0010886 ISO
    cellular response to hydroperoxide GO:0071447 ISO
    response to estradiol GO:0032355 IEP
    response to growth hormone GO:0060416 IEP
    negative regulation of transcription factor import into nucleus GO:0042992 ISO
    positive regulation of cytokine secretion GO:0050715 IMP
    cholesterol transport GO:0030301 ISO
    positive regulation of tumor necrosis factor production GO:0032760 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    pattern recognition receptor signaling pathway GO:0002221 ISO
    cell surface receptor signaling pathway GO:0007166 ISO
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    positive regulation of reactive oxygen species metabolic process GO:2000379 ISO
    lipid storage GO:0019915 ISO
    response to mechanical stimulus GO:0009612 IMP
    fatty acid transport GO:0015908 IMP
    long-chain fatty acid metabolic process GO:0001676 IMP
    positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO
    positive regulation of MAPK cascade GO:0043410 ISO
    lipoprotein transport GO:0042953 ISO
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
    negative regulation of gene expression GO:0010629 ISO
    cellular response to bacterial lipopeptide GO:0071221 ISO
    positive regulation of blood coagulation GO:0030194 ISO
    phagocytosis, recognition GO:0006910 ISO
    cellular response to lipopolysaccharide GO:0071222 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    plasma membrane long-chain fatty acid transport GO:0015911 ISO
    cellular response to lipoteichoic acid GO:0071223 ISO
    low-density lipoprotein particle clearance GO:0034383 ISO
    regulation of removal of superoxide radicals GO:2000121 ISO
    low-density lipoprotein particle mediated signaling GO:0055096 ISO
    fatty acid oxidation GO:0019395 IMP
    defense response to Gram-positive bacterium GO:0050830 ISO
    long-chain fatty acid transport GO:0015909 IMP
    positive regulation of macrophage cytokine production GO:0060907 ISO
    response to nutrient GO:0007584 IEP
    digestive tract development GO:0048565 IEP
    plasma lipoprotein particle clearance GO:0034381 ISO
    cellular response to insulin stimulus GO:0032869 IEP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    negative regulation of angiogenesis GO:0016525 IMP
    response to drug GO:0042493 IEP
    cell adhesion GO:0007155 IEA
    negative regulation of systemic arterial blood pressure GO:0003085 IMP
    apoptotic cell clearance GO:0043277 ISO
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    nitric oxide mediated signal transduction GO:0007263 ISO
    long-chain fatty acid import GO:0044539 ISO
    fatty acid metabolic process GO:0006631 IMP
    positive regulation of interleukin-6 production GO:0032755 ISO
    positive regulation of blood microparticle formation GO:2000334 ISO
    positive regulation of interleukin-12 production GO:0032735 ISO
    response to activity GO:0014823 IEP
    signal transduction GO:0007165 IDA
    negative regulation of growth of symbiont in host GO:0044130 ISO
    triglyceride metabolic process GO:0006641 IMP
Subcellular Localization
    sarcolemma GO:0042383 IDA
    integral component of membrane GO:0016021 IEA
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    apical part of cell GO:0045177 IDA
    mitochondrion GO:0005739 IDA
    protein complex GO:0043234 IDA
    endoplasmic reticulum GO:0005783 IDA
    membrane raft GO:0045121 ISO
    intracellular GO:0005622 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    Golgi apparatus GO:0005794 ISO
    external side of plasma membrane GO:0009897 ISO
    caveola GO:0005901 IDA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Cd36 in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Cd36
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd36 is involved
No pathways found

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