Gene description for Cd63
Gene name Cd63 molecule
Gene symbol Cd63
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cd63
ExoCarta ExoCarta_29186
Entrez Gene 29186
UniProt P28648  
 Cd63 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Cd63
Molecular Function
    protein complex binding GO:0032403 IDA
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell differentiation GO:0030855 IMP
    endosome to melanosome transport GO:0035646 ISS
    regulation of vascular endothelial growth factor signaling pathway GO:1900746 ISS
    positive regulation of cell adhesion GO:0045785 IMP
    positive regulation of receptor internalization GO:0002092 ISS
    pigmentation GO:0043473 ISO
    cell migration GO:0016477 ISS
    pigment granule maturation GO:0048757 ISS
    pigment cell differentiation GO:0050931 ISO
    negative regulation of epithelial cell migration GO:0010633 IMP
    regulation of rubidium ion transport GO:2000680 ISO
    cell-matrix adhesion GO:0007160 ISS
    cellular protein localization GO:0034613 ISO
    protein transport GO:0015031 IEA
    positive regulation of integrin-mediated signaling pathway GO:2001046 ISS
    positive regulation of endocytosis GO:0045807 IMP
Subcellular Localization
    protein complex GO:0043234 IDA
    extracellular exosome GO:0070062 ISO
    intrinsic component of plasma membrane GO:0031226 ISS
    melanosome GO:0042470 IEA
    transport vesicle membrane GO:0030658 IEA
    lysosome GO:0005764 ISO
    endosome lumen GO:0031904 ISO
    plasma membrane GO:0005886 IDA
    lysosomal membrane GO:0005765 ISS
    multivesicular body, internal vesicle GO:0097487 ISS
    cell surface GO:0009986 ISO
    cytoplasm GO:0005737 IDA
    late endosome GO:0005770 ISO
    endosome membrane GO:0010008 ISO
    integral component of membrane GO:0016021 TAS
    late endosome membrane GO:0031902 ISS
 Experiment description of studies that identified Cd63 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cd63
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cd63 is involved
No pathways found





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